✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Amitriptyline Hydrochloride
💊 Indication:	Depression, Neuropathic Pain, Migraine Prophylaxis, Insomnia
🇺🇸 US Brand:	Elavil
🏭 Manufacturer:	Intas Pharmaceuticals Ltd. (Founded: 1984)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	75 mg
🚚 Delivery Time:	6–15 days

🌿 What is Amitriptyline 75 mg (Amitone)?

Amitone contains Amitriptyline, a tricyclic antidepressant (TCA) that enhances neurotransmitter levels—serotonin and norepinephrine—in the brain. It is widely used for major depressive disorder, neuropathic pain, migraine prophylaxis, and insomnia. In depression, Amitriptyline helps restore mood balance, while in neuropathic pain, it modulates pain pathways to reduce chronic discomfort.

Clinical studies indicate that a 75 mg dose at bedtime not only improves mood symptoms but also enhances sleep quality. Moreover, Amitriptyline’s efficacy in preventing migraine attacks makes it a versatile option for patients with coexisting mood and pain disorders.

For detailed prescribing information and safety warnings, refer to the FDA label for Elavil (Amitriptyline) and the Drugs.com monograph. Additional clinical guidance is available from the NHS Medicines A–Z and the WHO Model List of Essential Medicines.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C20H23N2O
Molecular Weight	313.41 g/mol
Bioavailability	~30–50%
Metabolism	Hepatic (CYP2D6)
Half-Life	~20–50 hours

Amitriptyline blocks reuptake of neurotransmitters and also antagonizes certain receptors, contributing to side effects and therapeutic effects.

💡 Indications & Dosage

Condition	Typical Dose
Major Depression	75–150 mg once daily at bedtime
Neuropathic Pain	10–75 mg once daily; adjust based on response
Migraine Prophylaxis	10–75 mg at bedtime
Insomnia (off-label)	10–50 mg at bedtime

Start low (10–25 mg) and titrate weekly to minimize side effects.

⚠️ Warnings & Side Effects

Common:

Drowsiness, dry mouth, constipation
Blurred vision, urinary retention

Serious:

Cardiac arrhythmias (QT prolongation)
Orthostatic hypotension
Seizures

Monitor ECG in high-risk patients. Avoid abrupt discontinuation to prevent withdrawal.

🏥 Storage Instructions

Store Amitone at 20–25°C in original packaging. Protect from light and moisture. Keep out of reach of children.

🌐 Availability & Purchasing

United States: Prescription-only; generic and brand Elavil available.
United Kingdom & Europe: Prescription required; generics available.
Australia: Prescription necessary; TGA-approved.

Importing from India can lower cost; ensure valid prescription and compliance.

🔗 Related Therapies

Nortriptyline 25 mg – tricyclic antidepressant.
Gabapentin 300 mg – neuropathic pain agent.
Propranolol 40 mg – migraine prophylaxis.
Sertraline 50 mg – SSRI antidepressant.
Zolpidem 10 mg – insomnia treatment.

🎥 Educational Video on Amitriptyline

👩‍⚕️ Expert Commentary: Dr. Rahul Mehta, Psychiatrist

“Amitriptyline remains a versatile choice for depression and neuropathic pain, but requires careful dose titration and monitoring for anticholinergic and cardiac effects.”