🔬 Active Ingredient (Generic Name):	Azathioprine
💊 Indication:	Autoimmune Disorders (RA, IBD, SLE), Organ Transplant Rejection Prophylaxis
🇺🇸 US Brand:	Imuran
🏭 Manufacturer:	RPG Life Sciences Ltd. (Founded: 1983)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	75 mg
🚚 Delivery Time:	6–15 days

🌿 What is Azathioprine 75 mg (Azoran)?

Azoran contains Azathioprine, a purine analog prodrug that modulates immune response by inhibiting DNA synthesis in proliferating T and B lymphocytes. It is used to maintain remission in rheumatoid arthritis (RA), inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and to prevent rejection in organ transplantation.

Azathioprine’s immunosuppressive effect typically begins within 2–4 weeks of therapy, with full benefit at 3–6 months. Its steroid-sparing properties reduce long-term corticosteroid requirements and associated side effects.

For detailed prescribing and safety information, refer to the FDA label for Imuran and the Drugs.com monograph. Further guidance is available via the NHS Medicines A–Z and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C9H7N7O2S
Molecular Weight	277.28 g/mol
Bioavailability	~88%
Metabolism	Hepatic (TPMT, XO)
Half-Life	~5 hours

Azathioprine converts to 6-mercaptopurine, blocking purine synthesis and lymphocyte proliferation.

💡 Indications & Dosing

Condition	Dose
RA, SLE, IBD Maintenance	1–3 mg/kg once daily
Organ Transplant Rejection Prophylaxis	1–2 mg/kg once daily

Start at lower end; adjust per response and TPMT enzyme activity. Monitor CBC and liver function regularly.

⚠️ Warnings & Side Effects

Common:

Nausea, vomiting, diarrhea
Leukopenia, thrombocytopenia
Elevated liver enzymes

Serious:

Bone marrow suppression
Hepatotoxicity
Increased risk of malignancy (lymphoma)

Perform baseline TPMT testing. Monitor blood counts and LFTs monthly initially, then every 3 months.

🏥 Storage Instructions

Store at 20–25°C, protected from moisture. Keep tablets in original blister until use.

🌐 Availability & Purchasing

USA: Prescription-only (Imuran®); generics available.
UK & EU: Prescription required.
Australia: Prescription and regulatory approval required.

Importing from India may lower cost; ensure adherence to local regulations and valid prescription.

🔗 Related Immunosuppressive Therapies

Methotrexate 7.5 mg – RA anchor drug.
Azathioprine 50 mg (Imuran) – alternative strength.
Mycophenolate Mofetil – transplant rejection prophylaxis.
Cyclophosphamide – severe autoimmune conditions.
Prednisolone 5 mg – corticosteroid adjunct.

🎥 Educational Video on Azathioprine

👩‍⚕️ Expert Insight: Dr. Karan Mehra, Rheumatologist

“Azathioprine remains a cornerstone in long-term management of autoimmune diseases and transplant patients. TPMT testing and regular monitoring are essential to maximize safety.”