🔬 Active Ingredient (Generic Name):	Baclofen
💊 Indication:	Muscle Spasticity
🇺🇸 US Brand:	Lioresal
🏭 Manufacturer:	Novartis India Ltd. (Founded: 1994)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	10 mg
🚚 Delivery Time:	6–15 days

🌿 What is Baclofen 10 mg (Lioresal)?

Lioresal contains Baclofen, a gamma-aminobutyric acid (GABA)B receptor agonist that relaxes skeletal muscle by inhibiting monosynaptic and polysynaptic reflex transmission in the spinal cord. It is primarily indicated for muscle spasticity due to multiple sclerosis, spinal cord injury, or cerebral palsy. Lioresal’s efficacy in reducing muscle tone improves mobility and decreases discomfort associated with involuntary spasms.

Pharmacokinetic studies show that Baclofen is rapidly absorbed, reaching peak plasma levels within 1–2 hours, and has a half-life of 3–4 hours. This permits administration three times daily for stable symptom control. Clinical guidelines recommend starting at 5 mg three times daily and titrating to 10–20 mg three times daily as tolerated.

For detailed prescribing and safety information, consult the FDA label for Lioresal, the Drugs.com monograph, the NHS Medicines A–Z entry, and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C4H9Cl2NO
Molecular Weight	213.04 g/mol
Bioavailability	~70–80%
Metabolism	Minimal hepatic metabolism
Half-Life	3–4 hours

Baclofen’s action on GABAB receptors decreases excitatory neurotransmitter release, thereby reducing muscle overactivity.

💡 Indications & Dosing

Condition	Dose
Muscle Spasticity	Start 5 mg three times daily; may increase to 10 mg three times daily
Spinal Cord Injury & Cerebral Palsy	Titrate gradually up to 20 mg three times daily

Administration with food may reduce gastrointestinal discomfort. Dose adjustments required in renal impairment.

⚠️ Warnings & Side Effects

Common:

Drowsiness, dizziness
Weakness, fatigue
Nausea

Serious (rare):

Seizures (abrupt withdrawal)
Hypotension
Hallucinations

Avoid abrupt discontinuation to prevent withdrawal symptoms. Use caution when driving or operating machinery.

🏥 Storage Instructions

Store Lioresal at 20–25°C, in original blister to protect from moisture. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only as Lioresal; generic Baclofen also available.
UK & EU: Prescription required; Baclofen generics widely available.
Australia: Prescription and TGA approval for import.

Importing from India may offer cost benefits; ensure valid prescription and local regulatory compliance.

🔗 Related Muscle Relaxants

Liofen 10 mg – Baclofen by Sun Pharma.
Tizanidine 2 mg – Tizanidine.
Cyclobenzaprine 15 mg ER – Cyclobenzaprine ER.
Methocarbamol 500 mg – Robaxin.
Metaxalone 400 mg – Metaxalone.

🎥 Educational Video on Baclofen

👨‍⚕️ Expert Insight: Dr. Ravi Shah, Neurologist

“Baclofen is the first-line agent for managing spasticity due to its effective action on spinal reflexes. Lioresal’s well-established safety profile makes it a reliable choice for long-term therapy.”