✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Cilostazol
💊 Indication:	Intermittent Claudication, Peripheral Arterial Disease
🇺🇸 US Brand:	Pletal
🏭 Manufacturer:	Cipla Limited (Founded: 1935)
📦 Packaging:	10 Tablets per Strip
🧪 Strengths:	50 mg, 100 mg
🚚 Delivery Time:	6–15 days

🌿 What is Cilostazol (Pletoz)?

Pletoz contains Cilostazol, a selective phosphodiesterase III inhibitor that increases cyclic AMP in platelets and vascular smooth muscle. This dual action inhibits platelet aggregation and promotes vasodilation, improving symptoms of intermittent claudication and walking distance in patients with peripheral arterial disease (PAD).

Clinical trials demonstrate that Cilostazol 50 mg twice daily increases pain-free walking distance by up to 40% after 12 weeks compared to placebo. Its antiplatelet and vasodilatory effects make it an effective alternative when aspirin or clopidogrel are inadequate.

For prescribing information and safety details, refer to the FDA label for Pletal and the Drugs.com monograph. Additional guidance is available via the NHS Medicines A–Z entry and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C20H27N3O2
Molecular Weight	369.44 g/mol
Bioavailability	~90%
Metabolism	Hepatic (CYP3A4, CYP2C19)
Half-Life	~11–13 hours

Cilostazol’s inhibition of PDE III elevates cAMP, decreasing platelet activation and causing arterial dilation.

💡 Indications & Dosing

Condition	Dosage
Intermittent Claudication/PAD	50 mg twice daily or 100 mg twice daily, at least 30 minutes before or 2 hours after meals

Adherence to timing relative to meals is crucial for optimal absorption.

⚠️ Warnings & Side Effects

Common:

Headache, diarrhea
Palpitations, tachycardia
Dizziness

Serious:

Bleeding (due to antiplatelet effect)
Heart failure exacerbation (contraindicated in CHF)
Arrhythmias

Contraindicated in patients with heart failure or recent myocardial infarction. Monitor heart rate and signs of bleeding.

🏥 Storage Instructions

Store Pletoz at 20–25°C, in original blister packaging. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Pletal).
UK & EU: Prescription required; Cilostazol generics available.
Australia: Prescription and TGA approval needed.

Import from India can reduce costs; ensure compliance with local regulations and maintain a valid prescription.

🔗 Related Vascular Therapies

Pentoxifylline 400 mg – hemorheologic agent.
Rivaroxaban 2.5 mg – dual pathway inhibition.

🎥 Educational Video on Cilostazol

👨‍⚕️ Expert Insight: Dr. Kavita Sharma, Vascular Specialist

“Cilostazol 50 mg is a key treatment for PAD, improving walking distance and quality of life. Its cardiotonic and antiplatelet effects require caution in heart failure patients.”