🌙 Agomelatine 25 mg Tablets — Generic Valdoxan / Thymanax (Melatonergic Antidepressant)

Sleep-friendly antidepressant for Major Depressive Disorder • Melatonin receptor agonist & 5-HT_2C antagonist • Worldwide delivery via BuyAllMD

Agomelatine 25 mg is a modern antidepressant that acts as a melatonin MT₁/MT₂ receptor agonist and a
5-HT_2C serotonin receptor antagonist, approved in many countries for the treatment of
Major Depressive Disorder (MDD) in adults.
It is best known under the original brands Valdoxan® and Thymanax®, and is often chosen for patients who need an antidepressant that
supports sleep and circadian rhythm with a low risk of sexual dysfunction or weight gain compared to many SSRIs/SNRIs.

🧾 Product Overview

Product Name	Agomelatine 25 mg Tablets
Active Ingredient	Agomelatine
Strength	25 mg film-coated tablet (standard adult dose)
Dosage Form	Oral tablet (usually taken at bedtime)
Therapeutic Class	Melatonergic antidepressant (MT₁/MT₂ agonist, 5-HT_2C antagonist)
Reference Brands	Valdoxan® / Thymanax® (agomelatine)
Primary Indication	Major Depressive Disorder (MDD) in adults
Typical Packaging	7, 14 or 28 tablets per blister pack (varies by manufacturer)
Estimated Delivery	Australia 6–12 days • USA 8–18 days • UK/EU 10–20 days

🧠 How Agomelatine Works

Unlike classic SSRIs and SNRIs, agomelatine does not primarily work by inhibiting serotonin or noradrenaline reuptake.
Its antidepressant action is thought to come from two synergistic mechanisms:

MT₁/MT₂ receptor agonism: Agomelatine mimics melatonin at MT₁ and MT₂ receptors in the suprachiasmatic nucleus,
helping resynchronise circadian rhythms, improve sleep onset and quality, and stabilise the sleep–wake cycle.
5-HT_2C receptor antagonism: By blocking 5-HT_2C receptors, agomelatine indirectly increases dopamine and noradrenaline release
in the frontal cortex, supporting mood, motivation and cognitive function.

Clinically, this dual mechanism may translate into improved mood plus better sleep and daytime functioning, with fewer sexual side effects and
less weight gain than many conventional antidepressants, although individual responses vary.

🎯 Indications & Patient Profile

Major Depressive Disorder (MDD) in adults — including moderate to severe episodes.
Particularly considered where:
- Depression is strongly linked with sleep disturbance or circadian rhythm disruption.
- Patients have previously experienced sexual dysfunction, emotional blunting or weight gain on SSRIs/SNRIs.
- There is a need for a non-sedating daytime profile but better sleep at night.
Use in adolescents or elderly patients depends on local guidelines and specialist judgment.

💊 Dosage & Administration — Agomelatine 25 mg

Dosing must always follow the instructions of a psychiatrist or other qualified prescriber, especially because liver monitoring is required.
The table below reflects common adult regimens used with Valdoxan®/Thymanax® labels:

Use Scenario	Typical Dose	Timing	Notes
Initial treatment of MDD (adult)	25 mg	Once daily at bedtime	Review after ~2 weeks to assess response and tolerability.
Insufficient response after a few weeks	50 mg (two 25 mg tablets)	Once daily at bedtime	Maximum recommended dose; only under close medical supervision.
Continuation & maintenance	25–50 mg	At bedtime	Treatment is usually maintained for at least 6 months after remission to reduce relapse risk.

💡 Administration tips: Take the tablet whole with water at night. Do not exceed the prescribed dose. If a dose is missed, take the next one at the usual time (do not double up).

🧪 Liver Function Monitoring (Important!)

A key safety requirement with agomelatine is regular liver function testing (LFTs).
The medicine is contraindicated in active liver disease or when baseline transaminases exceed upper normal limits, and can cause dose-related increases in liver enzymes or, rarely, serious hepatotoxicity.

LFTs are typically checked before starting treatment.
Then repeated after about 3, 6, 12 and 24 weeks of therapy, and thereafter as clinically indicated.
If ALT/AST rise to >3× upper limit of normal, the medicine is usually stopped and LFTs monitored until normalisation.
Patients should promptly report symptoms such as unusual fatigue, dark urine, yellowing of skin/eyes, right-upper abdominal pain.

✅ Potential Advantages of Agomelatine 25 mg

Sleep & circadian support: Often improves sleep onset/quality without next-day sedation for many patients.
Low risk of sexual dysfunction: Compared with many SSRIs/SNRIs, sexual side effects appear less frequent.
Weight & metabolic profile: Generally neutral in short- to medium-term trials (individual variation applies).
No discontinuation syndrome typical of some SSRIs — agomelatine can usually be stopped without taper, though many doctors still prefer gradual reduction.
Alternative mechanism: Useful after inadequate response or poor tolerability on conventional serotonergic antidepressants.

⚠️ Side Effects & Precautions

Like all antidepressants, agomelatine can cause side effects and is not suitable for everyone.

Common: headache, dizziness, nausea, diarrhoea or constipation, dry mouth, increased sweating, back pain, fatigue or drowsiness.
Liver-related: asymptomatic elevations in liver enzymes are not uncommon; serious hepatotoxicity is rare but possible, hence mandatory LFTs.
Psychiatric: as with other antidepressants, worsening depression, agitation, or suicidal thoughts may occur, especially early in treatment or when doses change.
Other: anxiety, nightmares or vivid dreams, weight changes in some patients.

🚫 Agomelatine is typically avoided or used with extreme caution in: significant hepatic impairment, uncontrolled alcohol misuse, pregnancy/breast-feeding (risk–benefit must be carefully weighed), and in combination with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin), which can markedly increase agomelatine levels.

👨‍⚕️ Doctor’s Expert Opinion

“Agomelatine is an interesting option in the antidepressant toolbox, particularly for adults whose depression is tightly linked to
sleep disruption and circadian misalignment.
In my practice, it can be a good choice after SSRI/SNRI intolerance or emotional blunting, provided that baseline liver function is normal and regular monitoring is respected.
Patients should understand that it is not a sleeping pill, not a vitamin, and certainly not a self-medication drug — it is a full-strength antidepressant requiring proper psychiatric follow-up.”
— Dr. R. Singh, Consultant Psychiatrist

🌍 Global Shipping & Availability via BuyAllMD

Region	Agomelatine Availability	Estimated Delivery
Australia	Generic Valdoxan 25 mg — shipped from licensed Indian manufacturers	6–12 days*
USA	Available as overseas generic; prescription/psychiatric supervision strongly advised	8–18 days*
UK / EU	Shipped as generic agomelatine; check local rules for personal import & prescription	10–20 days*

*Transit times are indicative only and may vary with customs checks, routing changes, or public holidays.

🔗 Related CNS & Sleep-Linked Medicines on BuyAllMD

Product	Main Use	Class	Product Page
Escitalopram 10 mg	Depression & generalised anxiety	SSRI antidepressant	Escitalopram
Sertraline 50 mg	Depression, OCD, panic disorder	SSRI antidepressant	Sertraline
Clonazepam 0.5 mg	Seizure & anxiety disorders (short-term)	Benzodiazepine	Clonazepam
Melatonin 3 mg	Sleep onset & jet lag	Hormone / sleep aid	Melatonin

📚 External Medical References (Agomelatine / Valdoxan)

🩺 Medical & Legal Disclaimer

This article is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment.
Agomelatine is a prescription-only antidepressant that should be initiated and monitored only by a qualified mental-health professional,
with appropriate liver function testing and follow-up.
Never start, stop, or change psychiatric medication on your own. If you experience suicidal thoughts, severe mood changes, or signs of liver problems
(fatigue, dark urine, yellowing of skin/eyes), seek urgent medical help.
BuyAllMD supplies Indian-manufactured medicines with discreet international shipping; compliance with your country’s prescription, psychiatric care, and import laws
is solely the buyer’s responsibility.