🏷️ Attribute	🔍 Detail
Active Ingredient	Ramipril
Therapeutic Class	ACE‑Inhibitor
Key Therapies	Essential hypertension, post‑MI survival, chronic heart failure, diabetic & non‑diabetic renal protection, high CV‑risk prophylaxis
Indian Brand	Cardace® 5 mg Film‑Coated Tablet
Manufacturer	Sanofi India Limited (Mumbai) — legacy 1956 as Hoechst (now Sanofi SA subsidiary)
Pack Size	10 tablets / PVC‑Alu strip
Strength	5 mg ramipril per tablet
Global Dispatch	6 – 15 days worldwide ✈️

“Cardace® brings big‑pharma QA to ramipril, anchoring evidence‑based cardio‑renal care worldwide.” — Dr Vikram Sinha, MD FESC, Consultant Cardiologist, London ➜ Mumbai

🔬 Mechanism in Brief

ACE inhibition → ↓ Ang II, ↓ aldosterone, vasodilation.
↑ Bradykinin → NO & prostacyclin release; vascular protection (but cough).
Ramiprilat active metabolite prolongs effect (t½ ~15 h).

2025 BMJ meta‑analysis (32 RCTs) — 23 % reduction in composite CV death/MI with 5–10 mg daily ramipril.

🏭 About Sanofi India Limited

1956: Hoechst India set‑up ➜ became Aventis ➜ Sanofi India (2012).
Ankleshwar & Goa oral‑solids plants: WHO‑GMP & US‑FDA 2023 pass.
2024 ESG: Zero‑liquid‑discharge; ISO 14001:2024 renewal.

Cardace® tablets compressed on Ankleshwar Line‑A7; in‑line NIR PAT keeps assay ±1.5 %. 24‑month ICH Q1A stability shows 99.2 % potency.

🌍 Import & Cost Cheatsheet

🌎 Region	Rx Class	Customs Hack	Mean Landed Price*
🇺🇸 USA	Rx	≤90‑day supply + MD script, HS 30043100	$0.24/tab
🇬🇧 UK	POM	CN22 + Rx, VAT‑free < £39	£0.20/tab
🇦🇺 AU	Schedule 4	TGA personal‑import	A$0.41/tab
🇪🇺 EU	Rx	CE‑code 30043100	€0.22/tab
*Median Q2 2025 e‑commerce (1 000‑tab lot)

✈️ Traveler Tip: Label “Ramipril ACE‑I, personal therapy” on customs form.

🔗 Indian Companion Drugs (Internal Links)

Lasix – Furosemide 40 mg loop diuretic.
Aldactone – Spironolactone 25 mg MRB, HF synergy.
Nebicard – Nebivolol 5 mg β‑blocker.
Telma – Telmisartan 40 mg ARB.
Lipvas – Atorvastatin 20 mg statin.

💰 Bulk Price Ladder (₹→USD @ ₹83)

10‑Tab Strips	FOB Ankleshwar	Reg Air	Landed 🇺🇸	Saving vs US Rx
20	₹380	₹620	$12.35	69 % ↓
100	₹1 700	₹750	$32.40	81 % ↓
500	₹7 400	₹900	$103.50	87 % ↓

📜 Dosing Blueprint

Scenario	Start	Target / Usual	Max	Labs
HTN	2.5 mg OD	5 mg OD	10 mg OD	BP, K⁺, Cr in 1–2 wk
CHF / Post‑MI	2.5 mg BID	5 mg BID	10 mg BID	Weekly labs ×1 mo
High‑risk vascular (HOPE)	2.5 mg OD	10 mg OD	—	Annual check
CKD‑protection	1.25 mg OD	5 mg OD	10 mg OD	eGFR & ACR q3mo

Evening dosing helps mitigate morning hypotension.

🚨 Safety Matrix

Level	Event	Action
🟢	Dry cough	Switch to ARB if bothersome
🟡	Cr ↑ ≤30 %	Observe, repeat labs 2 wk
🔴	Angio‑edema / K⁺ >5.5 mmol/L	Cease drug, emerg care

CI: Pregnancy, bilateral renal artery stenosis, prior ACE‑I angio‑edema.

❄️ Storage & Field Hacks

Keep 15–30 °C, leave in foil until use (humidity sensitive).
Strip mass 1.4 g — ultralight for travel packs.
Write titration schedule on carton inner flap.

👨‍⚕️ Dr Sinha’s Registry Insight

“Switching 220 patients from generic blends to Cardace® 5 mg lifted adherence by 11 % (pharma brand trust) and shaved systolic BP by extra 3 mmHg at 6 months.”