🔬 Active Ingredient (Generic Name):	Topiramate
💊 Indications:	Epilepsy (Convulsive & Nonconvulsive), Migraine Prophylaxis
🇺🇸 US Brand:	Topamax
🏭 Manufacturer:	Intas Pharmaceuticals Ltd. (Founded: 1932)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	200 mg
🚚 Delivery Time:	6–15 days

🌿 What is Topiramate 200 mg (Topaz)?

Topaz 200 mg by Intas delivers a high-dose formulation of Topiramate, a broad-spectrum antiepileptic and migraine prophylactic. It modulates voltage-gated sodium channels, enhances GABAergic activity, antagonizes AMPA receptors, and inhibits carbonic anhydrase.

Clinical studies indicate that 200 mg daily provides robust seizure control, reducing frequency by over 70%, and decreases migraine days significantly in refractory cases. Starting at 25 mg and titrating weekly helps mitigate cognitive and weight loss side effects.

For prescribing details and safety information, refer to the FDA label for Topamax, the Drugs.com monograph, the NHS Medicines A–Z entry, and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C12H21NO8S
Molecular Weight	339.36 g/mol
Bioavailability	~80%
Metabolism	Minimal hepatic (50% excreted unchanged)
Half-Life	21 hours

Topiramate’s multi-mechanism approach stabilizes neuronal activity for seizure and migraine control.

💡 Indications & Dosing

Condition	Dose & Titration
Epilepsy (Adjunct/Monotherapy)	Start 25 mg nightly; increase by 25–50 mg weekly to 200 mg daily (in divided doses if needed)
Migraine Prophylaxis	50 mg nightly; titrate to 200 mg nightly

Adjust dose by patient response; reduce in renal impairment.

⚠️ Warnings & Side Effects

Common:

Paresthesia, somnolence
Cognitive impairment, weight loss
Taste perversion

Serious:

Metabolic acidosis
Nephrolithiasis
Glaucoma
Suicidal ideation

Monitor serum bicarbonate, renal function, and ocular health. Counsel on hydration and mood monitoring.

🏥 Storage Instructions

Store at 20–25°C in original blister to protect from moisture and light.

🌐 Availability & Purchasing

USA: Prescription-only; Topamax brand and generics.
UK & EU: Prescription required; generics available.
Australia: Prescription and TGA approval for import.

Importing from India can reduce cost; ensure compliance and valid prescription.

🔗 Related Neurological Therapies

Depakote ER (Divalproex) 125–500 mg – broad-spectrum AED.
Lamotrigine 100 mg – mood stabilizer and AED.
Levetiracetam 500 mg – adjunct AED.
Topirloc 50 mg & 100 mg – generic lower doses.

🎥 Video on Topiramate

👩‍⚕️ Expert Insight: Dr. Neeta Sharma, Neurologist

“Topiramate 200 mg (Topaz) offers potent control for refractory epilepsy and migraine. Gradual titration and monitoring minimize cognitive and metabolic adverse effects.”