✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Carbamazepine
💊 Indication:	Epilepsy (Partial & Generalized Tonic-Clonic Seizures), Trigeminal Neuralgia
🇺🇸 US Brand:	Tegretol
🏭 Manufacturer:	Sun Pharmaceutical Industries Ltd. (Founded: 1993)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	400 mg
🚚 Delivery Time:	6–15 days

🌿 What is Carbamazepine 400 mg (Zeptol)?

Zeptol contains Carbamazepine, an anticonvulsant and mood-stabilizing drug that blocks voltage-gated sodium channels, reducing neuronal excitability. It’s indicated for managing partial and generalized tonic-clonic seizures, as well as trigeminal neuralgia pain.

Once-daily 400 mg dosing achieves therapeutic plasma levels with improved adherence. Clinical studies confirm Zeptol’s efficacy in reducing seizure frequency by over 50% in refractory epilepsy and providing significant neuralgic pain relief.

For detailed prescribing and safety data, see the FDA label for Tegretol and the Drugs.com monograph. Additional guidance is available from the NHS Medicines A–Z entry and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C15H12N2O
Molecular Weight	236.27 g/mol
Bioavailability	~75%
Metabolism	Hepatic (CYP3A4)
Half-Life	12–17 hours

Carbamazepine stabilizes hyperexcited nerve membranes and inhibits repetitive neuronal firing by modulating sodium channels.

💡 Indications & Dosing

Condition	Dose & Titration
Partial & Generalized Tonic-Clonic Seizures	Start 400 mg once daily; increase by 200 mg weekly to 800–1,200 mg/day in divided doses
Trigeminal Neuralgia	200 mg twice daily; titrate up to 400 mg twice daily as needed

Administer with food to minimize GI upset. Therapeutic drug monitoring is recommended due to nonlinear kinetics.

⚠️ Warnings & Side Effects

Common:

Dizziness, drowsiness
Nausea, diplopia
Hyponatremia

Serious:

Serious dermatologic reactions (SJS/TEN) in HLA-B*1502 carriers
Blood dyscrasias (aplastic anemia, agranulocytosis)
Hepatotoxicity

Screen for HLA-B*1502 in at-risk populations. Monitor CBC, LFTs, and sodium. Counsel on rash reporting.

🏥 Storage Instructions

Store Zeptol at 20–25°C in original blister pack. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Tegretol); generics available.
UK & EU: Prescription required; generic carbamazepine widely available.
Australia: Prescription needed; TGA-approved.

Importing from India can offer cost benefits; ensure regulatory compliance and maintain a valid prescription.

🔗 Related Antiepileptic Drugs

Zeptol CR 200 mg – extended-release carbamazepine.

🎥 Educational Video on Carbamazepine

👩‍⚕️ Expert Insight: Dr. Neeta Sharma, Neurologist

“Zeptol 400 mg simplifies seizure management with once-daily dosing. Monitoring for HLA-B*1502 and blood parameters ensures safety in diverse patient populations.”