โ Active Ingredient Overview Table:
| ๐ฌ Active Ingredient (Generic Name): | Mirabegron |
|---|---|
| ๐ Indication: | Overactive Bladder (OAB): Urgency, Frequency, Urge Incontinence |
| ๐บ๐ธ US Brand: | Myrbetriq |
| ๐ญ Manufacturer: | Sun Pharmaceutical Industries Ltd. (Founded: 1993) |
| ๐ฆ Packaging: | 10 Tablets per Strip |
| ๐งช Strength: | 25 mg |
| ๐ Delivery Time: | 6โ15 days |
๐ฟ What is Mirabegron 25 mg (Mirago)?
Mirago 25 mg provides an effective starting dose of Mirabegron, a first-in-class ฮฒ3-adrenoceptor agonist designed to treat overactive bladder (OAB) by relaxing detrusor smooth muscle during the storage phase. This mechanism increases bladder capacity and reduces involuntary contractions, helping patients regain control over bladder function.
For many individuals experiencing bothersome symptoms such as sudden urges and frequent nighttime awakenings, the 25 mg dose offers significant improvements in daily quality of life. Clinical trials have demonstrated that Mirabegron 25 mg reduces daily micturition frequency by approximately 30% and decreases incontinence episodes by up to 35% compared to placebo over 12 weeks.
๐งฌ Pharmacology & Mechanism of Action
| Attribute | Detail |
|---|---|
| Chemical Formula | C21H24N2O2 |
| Molecular Weight | 344.43 g/mol |
| Bioavailability | ~29% |
| Metabolism | Hepatic (CYP3A4, CYP2D6) |
| Half-Life | ~50 hours |
Mirabegron selectively stimulates ฮฒ3 receptors in bladder detrusor muscle, increasing cyclic AMP to promote relaxation without affecting voiding contraction.
๐ก Indications & Dosing
| Condition | Dose & Administration |
|---|---|
| Overactive Bladder Symptoms | 25 mg once daily with water; may be taken with or without food |
The 25 mg dose is recommended for patients with mild to moderate symptoms or those requiring cautious initiation due to comorbidities. Dose may be increased to 50 mg based on response and tolerability.
โ ๏ธ Warnings & Side Effects
Common:
- Hypertension
- Headache
- Nasopharyngitis
Serious:
- Urinary retention
- Arrhythmias (rare)
- Severe hypertension
Use with caution in patients with moderate to severe hypertension and monitor blood pressure regularly. Avoid in those with severe bladder outlet obstruction.
๐ฅ Storage Instructions
Store Mirago 25 mg at 20โ25ยฐC in original blister packaging. Protect from moisture and light. Keep out of reach of children.
๐ Availability & Purchasing
- USA: Prescription-only (Myrbetriq 25 mg); brand and generic available.
- UK & EU: Prescription required; generic Mirabegron 25 mg available.
- Australia: Prescription and TGA approval required.
Importing from India may reduce cost; ensure compliance with regulations and maintain a valid prescription.
๐ Related OAB Therapies
- Mirago 50 mg โ higher dose.
- Solifenacin 5 mg โ M3 antagonist.
๐ฅ Educational Video on Mirabegron Therapy
๐ฉโโ๏ธ Expert Insight: Dr. Neha Kapoor, Urologist
โMirago 25 mg is an excellent initiation dose for new OAB patients, balancing efficacy and safety. Itโs perfect for those with mild symptoms or cardiovascular considerations.โ




