✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Mirabegron
💊 Indication:	Overactive Bladder (OAB): Urgency, Frequency, Urge Incontinence
🇺🇸 US Brand:	Myrbetriq
🏭 Manufacturer:	Cipla Limited (Founded: 1935)
📦 Packaging:	10 Extended-Release Tablets per Strip
🧪 Strength:	25 mg
🚚 Delivery Time:	6–15 days

🌿 What is Mirabegron 25 mg ER (VesiBeta ER)?

VesiBeta ER 25 mg features Mirabegron, a β3-adrenoceptor agonist that relaxes detrusor smooth muscle during the storage phase, increasing bladder capacity without anticholinergic side effects. This mechanism offers an alternative for patients intolerant to muscarinic antagonists.

Overactive bladder affects millions worldwide, leading to social anxiety, work disruption, and sleep disturbances. VesiBeta ER’s once-daily extended-release formulation ensures stable blood levels, reducing urinary urgency episodes by up to 40% and improving quality of life over 12 weeks of therapy.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C21H24N2O2
Molecular Weight	344.43 g/mol
Bioavailability	~29%
Metabolism	Hepatic (CYP3A4, CYP2D6)
Half-Life	~50 hours

Mirabegron selectively stimulates β3 receptors in the bladder, improving storage without significant cardiovascular impact when monitored appropriately.

💡 Indications & Dosing

Condition	Dose & Administration
Overactive Bladder Symptoms	25 mg ER once daily; swallow whole with water; may be taken with or without food

In clinical practice, dose may be increased to 50 mg ER based on response and tolerability. Monitor blood pressure, as mirabegron can cause mild increases in systolic BP.

⚠️ Warnings & Side Effects

Common:

Hypertension
Headache
Nasopharyngitis

Serious:

Acute urinary retention
Cardiac arrhythmias (rare)
Severe hypertension

Contraindicated in severe uncontrolled hypertension. Use caution in patients with bladder outlet obstruction. Monitor BP regularly and assess for urinary retention symptoms.

🏥 Storage Instructions

Store VesiBeta ER 25 mg at 20–25°C in its original pack. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Myrbetriq ER); branded and generic available.
UK & EU: Prescription required; generic mirabegron ER accessible.
Australia: Prescription and TGA approval required.

Importing from India may reduce costs; ensure compliance with local regulations and maintain a valid prescription.

🔗 Related Overactive Bladder Therapies

Solifenacin 10 mg – muscarinic antagonist.
Darifenacin 15 mg – M3 selective.
Tolterodine ER 4 mg – antimuscarinic ER.

🎥 Educational Video on Mirabegron

👩‍⚕️ Expert Insight: Dr. Kavita Desai, Urologist

“Mirabegron’s β3-agonist action provides a valuable, non-anticholinergic option for OAB patients, particularly those experiencing dry mouth or cognitive side effects with standard antimuscarinics.”