✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Mirabegron
💊 Indication:	Overactive Bladder (OAB): Urgency, Frequency, Urge Incontinence
🇺🇸 US Brand:	Myrbetriq
🏭 Manufacturer:	Cipla Limited (Founded: 1935)
📦 Packaging:	10 Extended-Release Tablets per Strip
🧪 Strength:	50 mg
🚚 Delivery Time:	6–15 days

🌿 What is Mirabegron 50 mg ER (VesiBeta ER)?

VesiBeta ER 50 mg represents the maximum once-daily dose of Mirabegron, offering robust relief of OAB symptoms for patients who require greater efficacy. By selectively activating β3-adrenoceptors in the bladder detrusor muscle, Mirabegron enhances bladder capacity and reduces involuntary contractions without the anticholinergic side effects common to other OAB treatments.

Patients experiencing severe urgency and leakage episodes may benefit from the 50 mg ER dose, which has been shown to reduce micturition frequency by up to 45% and incontinence episodes by 50% over placebo in clinical trials. The extended-release formulation maintains steady plasma levels, ensuring consistent symptom control throughout the day and night.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C21H24N2O2
Molecular Weight	344.43 g/mol
Bioavailability	~29%
Metabolism	Hepatic (CYP3A4, CYP2D6)
Half-Life	~50 hours

Mirabegron’s β3-agonist activity increases cyclic AMP in detrusor muscle cells, resulting in relaxation and improved storage without impacting voiding contraction.

💡 Indications & Dosing

Condition	Dose & Administration
Overactive Bladder Symptoms	50 mg ER once daily; swallow whole with water; may be taken with or without food

Monitor blood pressure at baseline and periodically, as Mirabegron can cause mild increases. For patients with significant hypertension, consider alternative therapies.

⚠️ Warnings & Side Effects

Common:

Hypertension
Headache
Nasopharyngitis

Serious:

Urinary retention
Arrhythmias (rare)
Severe hypertension

Use caution in patients with uncontrolled hypertension or severe bladder outlet obstruction. Monitor cardiovascular status and urinary function.

🏥 Storage Instructions

Store VesiBeta ER 50 mg at 20–25°C in the original strip. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Myrbetriq ER 50 mg); branded and generic forms.
UK & EU: Prescription required; generic extended-release Mirabegron available.
Australia: Prescription and TGA approval required.

International import from India may reduce cost; verify local regulations and have a valid prescription.

🔗 Related Overactive Bladder Therapies

VesiBeta ER 25 mg – lower Mirabegron dose.
Solifenacin 10 mg – M3 antagonist.
Tolterodine ER 4 mg – antimuscarinic ER.

🎥 Educational Video on Mirabegron and OAB

👩‍⚕️ Expert Insight: Dr. Neha Kapoor, Urologist

“The 50 mg ER dose of Mirabegron delivers maximal β3 receptor stimulation for patients with refractory OAB. Regular monitoring ensures safety and optimal benefit.”