✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Lidocaine Hydrochloride
💊 Indication:	Local Anesthesia, Ventricular Arrhythmias (IV infusion)
🇺🇸 US Brand:	Xylocaine
🏭 Manufacturer:	German Remedies Pvt Ltd (Founded: 1977)
📦 Packaging:	2% (20 mg/mL) in 30 mL Ampoule
🧪 Strength:	20 mg/mL (2%)
🚚 Delivery Time:	6–15 days

🌿 What is Lidocaine 2% Injection (Xylocaine)?

Xylocaine 2% Injection contains Lidocaine Hydrochloride, an amide-type local anesthetic that blocks sodium channels in nerve membranes, preventing depolarization and conduction of nerve impulses. It provides rapid-onset anesthesia for procedures and is also used intravenously to treat acute ventricular arrhythmias.

For comprehensive prescribing, administration guidelines, and safety information, consult the FDA label for Xylocaine Injection, the Drugs.com monograph, the NHS Medicines A–Z entry, and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C14H22N2O • HCl
Molecular Weight	270.80 g/mol (salt)
Onset of Action	2–5 minutes (infiltration); 1–2 minutes (IV)
Duration of Action	30–60 minutes (infiltration)
Metabolism	Hepatic (CYP1A2, CYP3A4)
Half-Life	1.5–2 hours (IV); prolonged in elderly/renal impairment

Lidocaine inhibits voltage-gated sodium channels, reducing nerve impulse transmission and providing sensory and motor blockade.

💡 Indications & Dosing

Use	Dose & Administration
Local/Regional Anesthesia	5–10 mL of 2% solution for infiltration or nerve block; max 300 mg per procedure (≤15 mL)
Ventricular Arrhythmias (IV)	1–1.5 mg/kg IV bolus over 2–3 min; may repeat 0.5–0.75 mg/kg every 5–10 min; infusion 1–4 mg/min

Always aspirate before injection to avoid intravascular administration during regional anesthesia. Adjust dose in hepatic dysfunction.

⚠️ Warnings & Side Effects

Common:

Local: redness, edema at injection site
Systemic: dizziness, tinnitus, metallic taste

Serious:

CNS: seizures, confusion, respiratory depression
Cardiovascular: hypotension, bradycardia, arrhythmias

Contraindicated in patients with hypersensitivity to amide anesthetics. Monitor ECG, BP, and respiratory status during IV administration.

🏥 Storage & Handling

Store at 20–25°C. Protect from light. Use aseptic technique. Discard unused portion of opened ampoule.

🌐 Availability & Purchasing

USA: Prescription-only; branded and generics.
UK & EU: Prescription required; widely available.
Australia: Prescription and TGA approval required.

Importing from India may provide cost advantages; verify regulatory requirements and possess valid prescription.

🎥 Educational Video on Lidocaine Use

👨‍⚕️ Expert Insight: Dr. Anil Sharma, Anesthesiologist

“Xylocaine 2% injection remains a mainstay for rapid-onset local anesthesia and acute ventricular arrhythmia management. Its safety profile is excellent when doses are appropriately calculated.”