Bexol

Trihexyphenidyl

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๐Ÿท๏ธย Parameter ๐Ÿ”ย Details
๐Ÿงฌ Active Ingredient Trihexyphenidyl Hydrochloride
๐Ÿ’Š Indication Parkinsonism, Drug-Induced Extrapyramidal Symptoms (EPS), Dystonia
๐Ÿ‡บ๐Ÿ‡ธ US Brand Artaneยฎ (discontinued); generic available
๐Ÿญ Manufacturer Intas Pharmaceuticals Ltd.
๐Ÿ“ฆ Packaging Blister strips of 10 tablets
๐Ÿ’ช Strength 2 mg
๐Ÿšš Delivery Time 7โ€“15 days (Worldwide)

๐Ÿง  Introduction to Bexol (Trihexyphenidyl)

Bexol containsย Trihexyphenidyl, a central anticholinergic agent manufactured by Intas India. It restores dopamine-acetylcholine balance in basal ganglia, providing relief for:

  • ๐Ÿฅผย Parkinson’s symptoms: Rigidity, tremors, and sialorrhea (excessive drooling)

  • ๐Ÿ’Šย Drug-induced EPS: Caused by antipsychotics (e.g., rigidity from Haloperidol)

  • ๐Ÿ’ชย Dystonia: Muscle spasms in neck/limbs (off-label)

Unlike levodopa, Bexol doesn’t cause dyskinesias but requires cautious dosing in elderly due to cognitive side effects.


๐Ÿ’Š Dosage & Indications

๐Ÿ’‰ย Indication ๐Ÿงชย Dosage โฑ๏ธย Frequency ๐Ÿ’กย Route
Parkinsonism (Adults) 1โ€“2 mg/day โ†’ Max 15 mg/day 3โ€“4 divided doses Oral
Drug-Induced EPS (Adults) 5โ€“15 mg/day Divided doses Oral
Dystonia (Off-label) 2โ€“5 mg TID Max 20 mg/day Oral
Pediatric EPS (โ‰ฅ3 years) 0.05โ€“0.1 mg/kg/day Divided doses Oral

โš ๏ธ Side Effects, Storage & Warnings

  • โ— Common Side Effects: Dry mouth, blurred vision, constipation, urinary retention.

  • ๐Ÿšซ Serious Effects:

    • Confusion/hallucinations (elderly)

    • Angle-closure glaucoma (emergency)

    • Tachycardia (heart rate >100 bpm)

  • โ„๏ธ Storage: Below 30ยฐC; protect from moisture (desiccant in bottle).

  • โš ๏ธ Warnings:

    • Contraindicated in glaucoma, myasthenia gravis, or bowel obstruction.

    • Avoid in dementia patients (โ†‘ cognitive impairment risk).

    • Discontinue gradually to prevent rebound symptoms.


๐ŸŒ Global Availability & Shipping

๐ŸŒŽย Region ๐Ÿ“ฆย Shipping ๐Ÿ’ตย Price (10 tablets) ๐Ÿ“œย Prescription
๐Ÿ‡บ๐Ÿ‡ธ USA โœ… Yes $15โ€“$25 Required
๐Ÿ‡ฌ๐Ÿ‡ง UK โœ… Yes ยฃ12โ€“ยฃ20 Required
๐Ÿ‡ฆ๐Ÿ‡บ Australia โœ… Yes AUD 20โ€“35 Required

๐Ÿ”— Related Indian Alternatives (Different in Same Category)

๐Ÿ’Š Product Name ๐Ÿญ Manufacturer ๐Ÿ”— Internal Link
Pacitane (Trihexyphenidyl) Sun Pharma Pacitane
Artane (Trihexyphenidyl) Pfizer Artane
Syndopa (Levodopa-Carbidopa) Sun Pharma Syndopa
Pramipex (Pramipexole) Intas Pramipex
Ropark (Ropinirole) Sun Pharma Ropark
Benexol (Benztropine) Alembic Pharma Benexol

๐Ÿ“š External Medical References

  1. Parkinson’s Foundation: Anticholinergics

  2. NIH: Drug-Induced Movement Disorders

  3. Trihexyphenidyl DrugBank Profile


๐Ÿฉบ Expert Commentary

Dr. Vikram Patel, Neurologist:
*”Bexol remains essential for young Parkinson’s patients with tremor-predominant symptoms. For antipsychotic-induced EPS, start with 2mg BID and monitor for anticholinergic toxicity. Rotigotine patches ([Neupro]) are preferable for elderly.”*

 


๐Ÿ“Œ Disclaimer

This article is informational only. Consult a neurologist before use. Intas’ Bexol is not FDA-approved for dystonia.


๐Ÿ’ก Clinical Tips:

  • Acute Dystonia Rescue: 5 mg IM + posture correction (onset: 10โ€“15 min).

  • Dry Mouth Management: Sugar-free gum/pilocarpine drops.

  • Switching Strategy: Replace 5 mg Bexol with 2 mg [Benexol] (less cognitive impact).

Additional Information

Active

Trihexyphenidyl

Tablets

30, 60, 90

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