🏷️ Parameter	🔍 Details
🧬 Active Ingredient	Nevirapine
💊 Indication	HIV-1 Infection (part of combination ART)
🇺🇸 US Brand	Viramune®
🏭 Manufacturer	Cipla Limited
📦 Packaging	60 tablets in 1 bottle (200 mg/tablet)
💪 Strength	200 mg
🚚 Delivery Time	7–14 days (Worldwide)

🧬 Introduction to Nevimune (Nevirapine)

Nevimune by Cipla contains Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 treatment. As part of combination antiretroviral therapy (ART), it:

🔬 Blocks HIV reverse transcriptase enzyme
📈 Increases CD4 counts
📉 Reduces viral load

Cipla’s 60-tablet bottle ensures 30-day supply for maintenance (200mg BID after lead-in). Not recommended for post-exposure prophylaxis (PEP) due to delayed efficacy.

💊 Dosage & Indications

💉 Indication	🧪 Dosage	⏱️ Frequency	💡 Notes
Adults (Initial)	200 mg/day (14-day lead-in)	Once daily	Monitor for rash
Adults (Maintenance)	200 mg BID	Twice daily	Start after lead-in
Children (≥15kg)	150–200 mg/m²/day	Twice daily	Max 400 mg/day
Hepatic Impairment	Avoid in moderate-severe	Contraindicated	ALT >5× ULN

⚠️ Side Effects, Storage & Warnings

❗ Common Side Effects: Rash (16%), headache, nausea, fatigue.
🚫 Serious Effects:
- Stevens-Johnson Syndrome (SJS)
- Hepatotoxicity (fatal in 1.2% of women CD4>250/mm³)
- Hypersensitivity reactions
❄️ Storage: 15–30°C; keep bottle tightly closed (desiccant included).
⚠️ Warnings:
- Contraindicated if CD4>250/mm³ (women) or CD4>400/mm³ (men)
- Discontinue permanently if rash with systemic symptoms
- Avoid in patients with HLA-DRB1*01 genotype

🌍 Global Availability & Shipping

🌎 Region	📦 Shipping	💵 Price (60-tablet bottle)	📜 Prescription
🇺🇸 USA	✅ Yes	$45–$70	Required
🇬🇧 UK	✅ Yes	£35–£60	Required
🇦🇺 Australia	✅ Yes	AUD 65–100	Required

🔗 Related Indian Alternatives (Different in Same Category)

💊 Product Name	🏭 Manufacturer	🔗 Internal Link
Efavir (Efavirenz)	Cipla	Efavir
Doluteg (Dolutegravir)	Emcure	Doluteg
Tenvir (Tenofovir)	Cipla	Tenvir
Lopimune (Lopinavir/Ritonavir)	Cipla	Lopimune
Viraday (Efavirenz/Emtricitabine/Tenofovir)	Cipla	Viraday
Abamune (Abacavir)	Cipla	Abamune

📚 External Medical References

🩺 Expert Commentary

Dr. Nisha Rao, HIV Specialist:
*”Nevimune requires strict adherence to the 14-day lead-in period to mitigate rash risks. For women with CD4>200/mm³, [Doluteg] (Dolutegravir) is safer. Always check HLA status – Cipla’s generic carries identical black-box warnings as Viramune.”*

📌 Disclaimer

This information is not medical advice. Use under physician supervision. Cipla’s Nevimune is contraindicated in occupational exposure prophylaxis.

💡 Clinical Protocol:

Rash Management:
- Grade 1-2 (localized): Continue + antihistamines
- Grade 3-4 (mucosal involvement): PERMANENT DISCONTINUATION
Liver Monitoring:
- Baseline ALT/AST → Repeat at 2, 4, 8 weeks
- Discontinue if ALT >5× ULN + symptoms
Cipla Bottle ID: White HDPE bottle with “NEVIMUNE-200” label
Drug Interactions:
- ↓ Effectiveness of hormonal contraceptives
- ↑ Methadone metabolism (monitor withdrawal)