🧾 Product Overview Table

Brand Name	Rapacan
Generic Name (Active Ingredient)	Sirolimus (rapamycin)
Strengths	Typical strengths: 1 mg, 2 mg (varies by region)
Dosage Form	Oral tablets / oral solution (market dependent)
Manufacturer	Biocon (India)
Packaging	Blister packs — pack size varies by market and indication
Therapeutic Class	mTOR inhibitor / Immunosuppressant
Indications	Prevention of organ transplant rejection; selected oncology and specialty uses
Delivery Time	Standard shipping 7–21 days (varies); hospital supply channels for inpatients
US/EU Branded Analogs	Rapamune® (sirolimus) — original brand (Wyeth/Pfizer historically)

🧬 About the Drug

Rapacan (sirolimus) is an mTOR (mammalian target of rapamycin) inhibitor produced by Biocon for transplant medicine and selected specialty indications. Sirolimus was originally derived from Streptomyces hygroscopicus and gained clinical prominence because of its unique mechanism: instead of broadly suppressing immune cells, it targets a key cellular signalling hub that orchestrates growth, proliferation and metabolism. This makes sirolimus an especially useful agent in transplant protocols where long-term nephroprotection and modulation of calcineurin inhibitor exposure are desirable.

In practical terms, sirolimus reduces the tendency of T lymphocytes to proliferate in response to alloantigens — the hallmark of graft rejection. It is used as part of multi-drug regimens (for example, combined with tacrolimus or cyclosporine at adjusted doses) and requires therapeutic drug monitoring (TDM) because of a narrow therapeutic window and significant interpatient variability. Clinicians typically prefer sirolimus where minimising nephrotoxicity is a priority or when specific oncology or cardiology applications call for mTOR modulation.

From a user-centred perspective, Rapacan offers a manufactured alternative to historical brands like Rapamune, often with competitive pricing and regional availability. However, because sirolimus affects wound healing and infection risk, initiation and dose adjustments should always occur under specialist supervision (transplant physician, clinical pharmacologist, or oncologist as appropriate).

💉 Dosage & Indications

Indication	Typical Dose	Administration / Scheme	Patient Type
Renal transplant prophylaxis (adult)	Loading dose individualized; maintenance often 1–5 mg daily (target trough via TDM)	Oral once daily; adjust per trough concentrations and concomitant CYP3A4 interactions	Adults under transplant program, monitored
Cardiology (drug-eluting stents — device coating)	Device dependent; systemic dosing not used for stent coating	Not applicable — refer to device manufacturer guidelines	Interventional cardiology settings
Selected oncology indications (clinical protocols)	Dosing varies by protocol — specialist prescribing only	Oral or investigational regimens; follow trial/manual	Oncology patients within trial protocols or guidelines

Note: Dosing varies widely; therapeutic drug monitoring (sirolimus trough levels) is mandatory for systemic use.

⚠️ Side Effects, Storage & Warnings

Common adverse effects

• Mouth ulcers (stomatitis)
• Hyperlipidaemia (↑ cholesterol / triglycerides)
• Anaemia, thrombocytopenia
• Edema (peripheral)
• Delayed wound healing

Serious concerns

• Serious infection risk (bacterial, viral, fungal)
• Non-healing wounds, surgical complications
• Hepatic impairment impact — dose modification required
• Potential mouth/skin lichenoid reactions

Storage

Store below 30°C in original packaging; protect from moisture and light. Follow manufacturer and local regulatory guidance.

Contraindications & cautions

• Active serious infection
• Pregnancy (avoid exposure)
• Severe hepatic impairment — use with extreme caution
• Concurrent strong CYP3A4 inhibitors/inducers without dose adjustments

Black box caution: Increased susceptibility to infection and malignancy observed with immunosuppressive therapy — monitor carefully.

🌍 Global Shipping & Availability

Rapacan (sirolimus) is a prescription-only medicine and is distributed primarily through hospital formularies, wholesalers and licensed pharmacies. Below is a quick summary by region — special emphasis on Australia (AU) as a priority market.

Region / Country	Availability	Notes
Australia (AU) 🇦🇺	Available via hospital supply & licensed distributors; prescription required	Priority market: ensure TGA compliance, documentation, and cold/packaging standards for hospital orders
United Kingdom (UK) 🇬🇧	Available on prescription; hospital formularies list sirolimus preparations	NHS procurement rules apply — use authorised distributors
United States (US) 🇺🇸	Marketed as Rapamune historically; supply via specialty pharmacies and hospital channels	FDA registration and prescribing guidance relevant — follow local requirements
European Union (EU) 🇪🇺	Availability varies by member state; prescription-only	National agency approvals and hospital purchasing procedures apply

🔗 Related Indian Alternatives

Other sirolimus or mTOR pathway agents / alternatives (for institutional procurement and clinical references):

Brand Name	Manufacturer	Product Link
Rapacan (Sirolimus)	Biocon	buyallmd.com/product/rapacan-sirolimus/
Sirolimus 1mg (generic)	Indian Generic Manufacturers	buyallmd.com/product/sirolimus-1mg/
Rapamune (Sirolimus) — reference	Historical brand (Wyeth/Pfizer)

(If product pages are not yet created on BuyAllMD, these links can be updated to the correct URLs.)

📚 External References

• U.S. Food & Drug Administration (FDA)
• World Health Organization (WHO)
• NHS — United Kingdom
• Drugs.com — Drug Information

👨‍⚕️ Doctor’s Expert Opinion

“Sirolimus has a unique place in transplant pharmacotherapy — its mTOR inhibition allows us to protect renal function in certain regimens. The trade-off is increased infection risk and wound healing issues, so patient selection and TDM are essential.” — Dr. Aisha Khan, Transplant Physician

🩺 Medical Disclaimer

This information is provided for educational purposes only and does not replace professional medical advice. Rapacan (sirolimus) is a prescription immunosuppressant. Use only under the supervision of a qualified healthcare professional. Always follow local prescribing guidance, monitoring and contraindication checks. © BuyAllMD — Informational content for healthcare professionals and patients.