🔬 Active Ingredient (Generic Name):	Celecoxib
💊 Indication:	Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Acute Pain, Dysmenorrhea
🏭 Manufacturer:	Cipla Ltd. (Founded: 1935)
📦 Packaging:	10 Capsules per Strip
🧪 Strengths:	100 mg, 200 mg
🚚 Delivery Time:	6–15 days

🌿 What is Celecoxib (Cobix)?

Cobix contains Celecoxib, a selective COX-2 inhibitor. By blocking COX-2, it reduces prostaglandins at inflammation sites while preserving COX-1–mediated gastric protection. Consequently, Cobix offers targeted relief with lower GI risk compared to traditional NSAIDs.

🧬 Chemical Profile & Mechanism

Attribute	Detail
Chemical Formula	C17H14F3N3O2S
Molecular Weight	381.37 g/mol
Bioavailability	~40%
Metabolism	Hepatic (CYP2C9)
Half-Life	~11 hours

Selecting COX-2 spares gastric mucosa, lowering ulceration risk while controlling pain.

💡 Indications & Usage

Osteoarthritis: 100 mg twice daily or 200 mg once daily.
Rheumatoid Arthritis: 100–200 mg twice daily.
Ankylosing Spondylitis: 200 mg once daily.
Acute Pain: 400 mg initial, then 200 mg as needed (max 400 mg/day).
Dysmenorrhea: 400 mg initial, then 200 mg as needed.

💊 Dosage Guidelines

Strength	Recommended Dose
100 mg	OA: 100 mg twice daily; RA: 100–200 mg twice daily
200 mg	AS: 200 mg once daily; Acute Pain/Dysmenorrhea: 400 mg initial, then 200 mg as needed

Take with food to reduce gastric irritation. Swallow capsules whole.

⚠️ Safety & Side Effects

Common:

Diarrhea, dyspepsia
Edema
Hypertension

Serious:

Cardiovascular risk (MI, stroke)
GI bleeding
Renal impairment

Use lowest effective dose. Monitor cardiovascular and renal status, especially in high-risk patients.

🏥 Storage Instructions

Store Cobix at 20–25°C in original packaging. Protect from moisture. Keep away from children.

🌐 Availability & Purchasing

USA & Canada: Prescription-only; brand and generics available.
UK & Europe: Prescription required; Celecoxib generics.
Australia: Prescription and TGA approval for some strengths.

Importing from India may cut costs; ensure regulatory compliance and valid prescription.

🔗 Related Medications

Meloxicam 15 mg – preferential COX-2 inhibitor.
Etoricoxib 60 mg – COX-2 inhibitor.
Ibuprofen 400 mg – non-selective NSAID.
Diclofenac SR 75 mg – extended-release NSAID.
Naproxen SR 750 mg – sustained-release NSAID.

🎥 Educational Video on Celecoxib

👨‍⚕️ Expert Insight: Dr. Priya Mehta, Rheumatologist

“Celecoxib provides effective arthritis relief with reduced GI risk. However, its cardiovascular profile demands careful patient selection and monitoring.”