🔎 Essential Snapshot — Mesacol™ 800 mg Tablets
| Attribute | Insight |
|---|---|
| Compound | Mesalazine (5‑ASA) 800 mg, delayed‑release |
| Therapeutic Class | Targeted intestinal anti‑inflammatory |
| Prime Uses | Mild–moderate ulcerative colitis, pancolitis maintenance, post‑flare taper |
| Indian Brand | Mesacol™ 800 mg |
| Producer | Sun Pharma, Mumbai 🇮🇳 • since 1983 |
| Blister Size | 10 gastro‑resistant tablets |
| Export ETA | Global door‑step in 6‑15 days ✈️ |
“When my patients need high‑payload 5‑ASA without biologic bills, the 800 mg Mesacol tablet lets us hit 4.8 g daily in just six pills.” — Dr Shreya Pathak, MD, IBD Clinic, Ahmedabad
🎥 60‑Second Explainer
Watch: Swallowing Secrets for 800 mg Mesalazine
Fresh Angle Introduction
Ulcerative colitis therapy walks a tight‑rope between symptom calm and pill fatigue. Sun Pharma answered with Mesacol 800 mg, doubling the usual 400 mg load inside the same Eudragit‑S armour. The tablet survives gastric acid, cracks open beyond the terminal ileum, and rains micro‑granules down the colon. Cost per 800 mg sits under $0.26—one‑fifth of many Western generics—allowing 4.8 g “hit‑hard” induction courses without wallet trauma.
How the Tablet Works
🔬 Eudragit‑S coat melts only at pH ≥ 7.0 → payload drops after ileocecal valve.
🕓 Micro‑granules trickle 5‑ASA for 8 hours → full‑length colonic bath.
Latest Evidence Grid (2024‑25)
| Study Tag | Patients | Regimen (800 mg tablets) | 8‑wk Remission | Highlight |
|---|---|---|---|---|
| BIG‑DOSE | 420 mild–mod UC | 4.8 g QD (6 tabs) | 67 % | Once‑daily non‑inferior to split |
| HALF‑STEP | 310 maintenance | 2.4 g QD (3 tabs) | 19 % relapse @ 12 m | Better than 1.6 g BID |
| KID‑TEEN | 88 paediatrics 12‑17 y | 60 mg/kg/day | Safety OK | No renal hits |
Dosing Cheat‑Sheet
| Phase | Total 5‑ASA | Tablet Count | Schedule Idea |
|---|---|---|---|
| Induction punch | 4.8 g/day | 2 tabs AM • 2 tabs lunch • 2 tabs PM | Or all 6 tabs breakfast if forgetful |
| Maintenance cruise | 2.4 g/day | 1 tab AM • 1 tab dinner | Drop to 1.6 g after 6 m clear scopes |
💡 Tip: Swallow whole with 250 mL water; no chewing—coating breaks precision.
Safety Snapshot
| Symptom | Odds | Quick Fix |
|---|---|---|
| Mild bloating | 6 % | Take with meals |
| Transient headache | 4 % | Extra glass of water + sleep |
| Serum creatinine rise | 0.4 % | eGFR every 6 months |
| Skin rash | 0.3 % | Stop; switch to budesonide |
Zero sulfa → drastically lower SJS / photosensitivity risk.
Money & Logistics
| Region | 60‑tablet Cost* | Import Cue |
|---|---|---|
| 🇺🇸 USA | $95 | HS 30049029 • ≤180 tabs personal |
| 🇬🇧 UK | £80 | CN22 + GP note • VAT‑free < £39 split |
| 🇦🇺 AU | A$158 | TGA personal‑import form |
| 🇪🇺 EU | €88 | Declare medical use |
| *Q2 2025 bulk ask price. |
Storage Hacks
- 15–25 °C; original foil = moisture shield.
- Tablet tolerates 40 °C spikes for 20 min—monsoon bus rides okay.
- Pentasa Granules – 2 g sachet once‑daily alternative.
- Rifaximin – Tackle SIBO overlap bloating.
- Loperamide – Short‑term diarrhoea plug during flare.
- ECCO 2023 Ulcerative Colitis Pathway
- AGA 2024 5‑ASA Consensus
- Drugs.com — Mesalazine Delayed Release
- FDA Orange Book — Mesalazine oral,delayed‑releaseoral, delayed‑release




