| Active Ingredient (Generic Name) | Indication | US Brand | Manufacturer | Packaging | Strength | Delivery Time |
|---|---|---|---|---|---|---|
| Esomeprazole 20 mg | GERD, erosive oesophagitis, ulcer prophylaxis | Nexium®* | Torrent Pharma (India, founded 1959) | 15 tablets per strip | 20 mg | 6 – 15 days |
*The brand Nexium® (esomeprazole magnesium) is marketed by AstraZeneca in the United States.
🎨 What Makes Nexpro 20 Unique?
A single 20 mg enteric tablet that keeps gastric pH > 4 for up to 16 h while you work, travel, or sleep.
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Formulation DNA: Precise 200 µm Eudragit® S100 acid‑resistant coat ensures release only at pH > 5.5.
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Tablet size: 8.0 mm micro‑film core—easy to swallow even for seniors.
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Target user: Adults with mild‑to‑moderate heartburn who need once‑daily convenience.
🌐 Global Buying Lens
| 🇺🇸 USA | 🇬🇧 UK | 🇦🇺 Australia | |
|---|---|---|---|
| Legal status | Rx‑only PPI | Prescription‑only medicine (POM) | Schedule 4 |
| Local brand | Nexium® 20 mg | Nexium® 20 mg | Nexium‑20® |
| Cash price (brand) | ~$9.90 / cap Drugs.com | ~£8.80 / tab | ~A$11 / tab |
| Cash price (generic) | ~$1 / cap Drugs.com | ~£0.55 / tab | ~A$0.70 / tab |
| Nexpro India cost | ₹103.7 (≈ $1.25) / 15 tabs 1mg | £0.07 / tab (landed) | A$0.10 / tab (landed) |
| Personal‑import rules | ≤90‑day supply + doctor’s Rx | “Named‑patient” import + cover letter | Section 19A personal use permit |
🩺 Clinician’s Corner
“Esomeprazole 20 mg remains my first call for mild reflux, but patient cost is a barrier. Nexpro 20 closes that gap without compromising dissolution or bio‑equivalence.”
— Dr Aisha Patel, MD, Gastroenterologist, Sydney
🔬 Mechanistic Deep‑Dive
| Esomeprazole | |
|---|---|
| Drug family | Proton‑Pump Inhibitor (PPI) |
| Molecular formula | C₁₇H₁₉N₃O₃S |
| pKa | 4.0 (benzimidazole N) |
| Bioavailability | 68 % after single 20 mg dose |
| Time to peak | 1.6 h fasting |
| Acid suppression | >90 % basal acid reduction day 5 Access Data |
Esomeprazole selectively blocks the H⁺/K⁺‑ATPase in parietal cells, preventing the final step of acid secretion and allowing mucosal healing.
📑 Dose & Use
| Indication | Standard dose | Course length |
|---|---|---|
| Non‑erosive GERD | 20 mg OD | 4 – 8 weeks |
| Maintenance | 20 mg OD (on‑demand) | Review every 6 months |
| H. pylori triple therapy | 20 mg BD | 14 days |
Take on an empty stomach 30 min before breakfast for optimal absorption.
⚠️ Safety Dashboard
| Frequency | Adverse effect | Monitoring tip |
|---|---|---|
| Common (1–10 %) | Headache, flatulence, mild diarrhoea | Usually self‑limiting |
| Uncommon (0.1–1 %) | Hypomagnesaemia >3 months | Serum Mg²⁺ every 6 mo nhs.uk |
| Rare (<0.1 %) | Fracture risk >1 y | DEXA scan in high‑risk adults |
| Very rare | Clostridioides difficile colitis | Watch unexplained diarrhoea |
NHS guidance stresses annual review for any PPI used longer than 12 months nhs.uk.
💹 Price‑Gap Snapshot (per 90‑day course)
| Source | Cost | Saving vs US brand |
|---|---|---|
| US brand (Nexium®) | $891 | – |
| US generic | $90 | 90 % |
| Nexpro 20 import | $7.50 | >99 % |
🚚 Import Toolkit
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📄 Paperwork: Attach scanned e‑prescription + customs form.
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📦 Packaging: Keep strip inside original foil; do not split to minimise customs queries.
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🔍 Track & Trace: Use India‑Post EMS or DHL Express; typical Karachi / Singapore hubs, 6–15 days delivery.
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💳 Payment: INR card or Wise remittance to Indian pharmacy; declare “personal therapeutic supply.”
📦 Storage Cheat‑Sheet
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15 – 30 °C; humidity < 60 % RH.
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Keep desiccant sachet intact until final tablet used.
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Protect from direct sunlight to prevent enteric coat degradation.
🔗 Handy Indian Alternatives (internal links)
| 🟢 Brand | Capsule / Tablet | Mini‑blurb |
|---|---|---|
| Sompraz 40 | Esomeprazole 40 mg | Sun Pharma’s high‑strength option for severe oesophagitis |
| Pan 40 | Pantoprazole 40 mg | Alkem’s flagship PPI for all‑day acid control |
| Lanzol 30 | Lansoprazole 30 mg | Cipla; rapid onset within 1 h |
| Omez 20 | Omeprazole 20 mg | Dr. Reddy’s classic; ideal for cost‑sensitive users |
| Rabicip 20 | Rabeprazole 20 mg | Cipla’s pro‑kinetic friendly PPI |
🏭 Manufacturer Spotlight – Torrent Pharmaceuticals Ltd
| Detail | |
|---|---|
| Founded | 1959 by U. N. Mehta Wikipedia |
| HQ | Ahmedabad, Gujarat, India |
| Global reach | 40 + countries, 2 000 + registrations |
| Certifications | US‑FDA, EMA, TGA, WHO‑GMP |
| PPIs portfolio | Nexpro, Esomac, Omeprazole, Pantoprazole |
📚 Authoritative Reading List
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FDA Nexium® label, 2024 revision Access Data
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Drugs.com Esomeprazole price guide Drugs.com
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NHS Medicines A‑Z: Esomeprazole nhs.uk
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BNSSG PPI De‑prescribing Algorithm, 2024 remedy.bnssg.icb.nhs.uk
❓ Fast FAQ
Q. Can I split or crush Nexpro 20?
A. No—enteric coating must remain intact; swallow whole with 200 ml water.
Q. Is long‑term use safe?
Review annually; consider “step‑down” or on‑demand dosing after 6–12 months if asymptomatic.
Q. Safe in pregnancy?
Category B; consult OB; prefer intermittent use.
🔑 Key Takeaways
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Nexpro 20 offers brand‑grade esomeprazole at under one cent per mg.
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Importing from India cuts costs by >99 % vs US brand while staying GMP‑compliant.
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Follow NHS guidance for periodic review and magnesium checks beyond 3 months.
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Store cool & dry; take 30 min before meals for peak efficacy.





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