- Your cart is empty
- Continue Shopping
Accufine 20 mg
Accufine 20 mg
Isotretinoin
Price range: $21.00 through $50.00
Capsules
Choose an option
✓ Discreet packaging
✓ 7–15 business days delivery
✓ Card, crypto & bank transfer
Add to cart
Buy Now
💊 Retinoid • Isotretinoin • Healing Pharma
💊 Accufine 20 mg — higher-dose isotretinoin by Healing Pharma. Generic alternative to Accutane®.
🔬 Active IngredientIsotretinoin
💊 IndicationSevere recalcitrant nodular acne; off-label: rosacea, hidradenitis suppurativa
🇺🇸 US BrandAccutane®, Claravis®
🏭 ManufacturerHealing Pharma
📦 Packaging10 capsules per strip
🧪 Strength20 mg per capsule
🌿 What Is Accufine 20 mg (Isotretinoin)?
Accufine 20 mg provides a higher daily dose of isotretinoin, accelerating the achievement of the cumulative therapeutic exposure (120–150 mg/kg). This strength is ideal for patients who need higher-intensity treatment to induce rapid decreases in sebum production and inflammatory lesion counts.
Traditional dosing may require several months to reach target cumulative levels. Using 20 mg capsules enables patients to increase daily intake with fewer capsules, improving adherence. Clinical evidence shows that higher daily dosing shortens treatment duration while maintaining comparable safety when monitored closely.
🧬 Pharmacology & Mechanism of Action
Chemical FormulaC₂₀H₂₈O₂
Molecular Weight300.44 g/mol
Bioavailability~25% (increases with high-fat meals)
MetabolismHepatic (CYP2C8, CYP2C9)
Half-Life10–20 hours
Isotretinoin modulates gene expression via retinoic acid receptors, leading to reduced sebocyte proliferation, normalized keratinization, and anti-inflammatory effects.
💡 Indications & Dosing
| Condition | Dose & Administration |
|---|---|
| Severe Nodular Acne | 20 mg once daily; titrate by body weight to achieve cumulative 120–150 mg/kg over ~8–12 weeks |
| Off-Label: Rosacea & Hidradenitis Suppurativa | 20 mg once daily for 3–6 months, adjust per response |
💡 Important: Take Accufine with a meal (high-fat optimal) to enhance absorption. Monitor weight to calculate cumulative dose and adjust duration accordingly.
⚠️ Warnings & Side Effects
❗ Common Side Effects
- Cheilitis (dry lips)
- Xerosis (dry skin)
- Skin fragility
- Photosensitivity
- Muscle aches
⚠️ Serious (Requires Immediate Attention)
- Teratogenicity — strict pregnancy prevention program mandatory
- Elevated triglycerides
- Hepatotoxicity
- Mood disturbances (rarely suicidal ideation)
⚠️ Pregnancy Warning: Isotretinoin is highly teratogenic (causes severe birth defects). Female patients of childbearing potential must use two contraception methods and have monthly pregnancy tests. Perform monthly LFTs, lipid panels, and mood assessments.
🏥 Storage Instructions
- Store at 20–25°C in original blister pack
- Protect from moisture and light
- Keep out of reach of children
🌐 Availability & Purchasing
- 🇺🇸 USA: Prescription-only (Accutane); isotretinoin under strict REMS.
- 🇬🇧 UK & EU: iPLEDGE equivalents require monitoring.
- 🇦🇺 Australia: Schedule 4 medicine; pregnancy prevention required.
Importing from India may reduce costs; ensure compliance with local guidelines and pregnancy prevention protocols.
🔗 Related Dermatologic Therapies
📺 Educational video: High-dose isotretinoin therapy — best practices and monitoring
👩⚕️ Dr. Anita Kapoor, Dermatologist
“High-dose isotretinoin like Accufine 20 mg can shorten treatment courses, but requires rigorous monitoring for lipid, hepatic, and mood changes to maintain safety.”
⚠️ Medical Disclaimer
This content is for educational purposes only and does not substitute for professional medical advice. Isotretinoin is a prescription medication with significant risks, including severe birth defects, mood changes, and liver damage. It should only be used under the supervision of a qualified dermatologist. Female patients must comply with strict pregnancy prevention programs. This information is for educational purposes only.
BuyAllMd.com — Your Reliable Global Pharmacy Partner Since 2015
🔐 Discreet Packaging • 💳 Multiple Payment Options • 📦 Guaranteed Reshipment • 🌍 Worldwide Shipping
Additional Information
| Active | Isotretinoin |
|---|---|
| Capsules | 30, 60, 90 |
Related products
