Amitone

✅ Active Ingredient Overview Table:

🌿 What is Amitriptyline 75 mg (Amitone)?

Amitone contains Amitriptyline, a tricyclic antidepressant (TCA) that enhances neurotransmitter levels—serotonin and norepinephrine—in the brain. It is widely used for major depressive disorder, neuropathic pain, migraine prophylaxis, and insomnia. In depression, Amitriptyline helps restore mood balance, while in neuropathic pain, it modulates pain pathways to reduce chronic discomfort.

Clinical studies indicate that a 75 mg dose at bedtime not only improves mood symptoms but also enhances sleep quality. Moreover, Amitriptyline’s efficacy in preventing migraine attacks makes it a versatile option for patients with coexisting mood and pain disorders.

For detailed prescribing information and safety warnings, refer to the FDA label for Elavil (Amitriptyline) and the Drugs.com monograph. Additional clinical guidance is available from the NHS Medicines A–Z and the WHO Model List of Essential Medicines.

🧬 Pharmacology & Mechanism of Action

Amitriptyline blocks reuptake of neurotransmitters and also antagonizes certain receptors, contributing to side effects and therapeutic effects.

💡 Indications & Dosage

Start low (10–25 mg) and titrate weekly to minimize side effects.

⚠️ Warnings & Side Effects

Common:

• Drowsiness, dry mouth, constipation
• Blurred vision, urinary retention

Serious:

• Cardiac arrhythmias (QT prolongation)
• Orthostatic hypotension
• Seizures

Monitor ECG in high-risk patients. Avoid abrupt discontinuation to prevent withdrawal.

🏥 Storage Instructions

Store Amitone at 20–25°C in original packaging. Protect from light and moisture. Keep out of reach of children.

🌐 Availability & Purchasing

• United States: Prescription-only; generic and brand Elavil available.
• United Kingdom & Europe: Prescription required; generics available.
• Australia: Prescription necessary; TGA-approved.

Importing from India can lower cost; ensure valid prescription and compliance.

🔗 Related Therapies

• Nortriptyline 25 mg – tricyclic antidepressant.
• Gabapentin 300 mg – neuropathic pain agent.
• Propranolol 40 mg – migraine prophylaxis.
• Sertraline 50 mg – SSRI antidepressant.
• Zolpidem 10 mg – insomnia treatment.

🎥 Educational Video on Amitriptyline

👩‍⚕️ Expert Commentary: Dr. Rahul Mehta, Psychiatrist

“Amitriptyline remains a versatile choice for depression and neuropathic pain, but requires careful dose titration and monitoring for anticholinergic and cardiac effects.”