Ampicillin/Sulbactam

Ampicillin/Sulbactam injection is a powerful antibiotic combination used to treat a wide range of bacterial infections, including severe and life-threatening cases. This injectable medication is a mixture of Ampicillin, a broad-spectrum penicillin antibiotic, and Sulbactam, a beta-lactamase inhibitor. The combination of these two active ingredients allows Ampicillin/Sulbactam to effectively combat bacteria resistant to conventional antibiotics.

Chemical Formula and Mechanism of Action

The chemical formula of Ampicillin/Sulbactam injection is C19H24N2O12S2. This medication works by inhibiting the growth of bacteria through the disruption of the bacterial cell wall and the inhibition of beta-lactamase enzymes, which can otherwise inactivate antibiotics. The Sulbactam component in particular helps to preserve the effectiveness of Ampicillin by protecting it from degradation.

Brand Names and Generic Manufacturers in India

Ampicillin/Sulbactam injection is available under various brand names worldwide, including:

• Unasyn
• Spectracef
• Bactocill
• Timentin
• Amplimune

In India, several generic manufacturers produce Ampicillin/Sulbactam injection, including:

• Torrent Pharmaceuticals
• Cipla
• Lupin
• Zydus Cadila
• Sandoz

Administration and Dosage

The dosage and administration of Ampicillin/Sulbactam injection depend on the severity and type of infection being treated. The typical dose for adults is 3 grams (1.5 grams of each component) administered intravenously over a period of 30 minutes to 1 hour. The dosing interval is usually every 6 to 8 hours, depending on the patient’s condition.

Side Effects and Precautions

While generally well-tolerated, Ampicillin/Sulbactam injection can cause side effects in some patients, including:

• Nausea and vomiting
• Diarrhea or abdominal pain
• Allergic reactions (rash, itching, difficulty breathing)
• Kidney damage or impaired kidney function

Importance of Precautions

Before administering Ampicillin/Sulbactam injection, it is essential to follow certain precautions, such as:

• Allergic reactions: Patients with a history of allergic reactions to penicillin or sulfonamides should not receive this medication.
• Kidney or liver dysfunction: Patients with pre-existing kidney or liver disease may require adjusted dosing or closer monitoring.
• Pregnancy or breastfeeding: The safety of Ampicillin/Sulbactam injection in pregnant or breastfeeding women is not well established.

Pricing Comparison Across Countries

Prices for Ampicillin/Sulbactam injection vary significantly across countries and pharmacies. Here’s a rough estimate of prices:

• Australia: $150-$300 per vial (3 grams)
• United States: $200-$400 per vial (3 grams)
• United Kingdom: £100-£200 per vial (3 grams)
• India: ₹500-₹1,000 per vial (3 grams)

Importing Ampicillin/Sulbactam Injection from India

While it is possible to import Ampicillin/Sulbactam injection from India, it is essential to follow regulations and ensure compliance with local laws. Patients should consult with a healthcare professional and check with their country’s regulations before importing prescription medication.

Conclusion

Ampicillin/Sulbactam injection is a powerful antibiotic combination used to treat a wide range of bacterial infections. Understanding its use, dosing, side effects, and pricing can help patients make informed healthcare decisions. By following the guidelines outlined in this article, patients can safely and effectively use Ampicillin/Sulbactam injection to combat bacterial infections.