Name: Augmentin Duo 625mg
SKU: 23577
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Amoxicillin 500 mg + Clavulanic Acid 125 mg
💊 Indication:	Bacterial Infections (Respiratory, Skin, ENT, Urinary)
🇺🇸 US Brand Equivalent:	Augmentin
🏭 Manufacturer:	GlaxoSmithKline Pharmaceuticals Ltd (Founded: 2000)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	625 mg (500/125 mg)
🚚 Delivery Time:	6–15 days

🌿 What is Augmentin Duo 625 mg?

Augmentin Duo 625 mg combines Amoxicillin, a broad-spectrum penicillin antibiotic, with Clavulanic Acid, a potent β-lactamase inhibitor. Clavulanic Acid protects Amoxicillin from degradation by β-lactamase enzymes produced by resistant bacteria, extending its spectrum to cover organisms like Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, and various anaerobes. Augmentin Duo is indicated for respiratory tract infections (sinusitis, otitis media, bronchitis, pneumonia), skin and soft tissue infections, urinary tract infections, and other β-lactamase–producing bacterial infections.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Amoxicillin 500 mg	• Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) → bactericidal activity.
Clavulanic Acid 125 mg	• Irreversibly inhibits β-lactamase enzymes → protects Amoxicillin from enzymatic degradation → restores activity against resistant strains.
Pharmacokinetics	• Absorption: ~75–80% oral bioavailability; food has minimal effect.
	• Distribution: Widely distributed; achieves therapeutic concentrations in middle ear fluid, sinuses, lung tissue, and urine.
	• Metabolism & Excretion: Excreted primarily unchanged via urine; Clavulanic Acid partially metabolized hepatically.
	• Half-Life: Amoxicillin: ~1 hour; Clavulanic Acid: ~1 hour.

💡 Indications & Usage

Condition	Recommended Course
Acute Otitis Media (≥3 months)	625 mg twice daily for 10 days (children: weight-based dosing, typically 20–45 mg/kg/day of Amoxicillin component)
Acute Bacterial Sinusitis	625 mg twice daily for 10–14 days (adjust in severe or refractory cases)
Community-Acquired Pneumonia (Adults)	625 mg three times daily for 7–10 days, depending on severity
Skin & Soft Tissue Infections (Uncomplicated)	625 mg twice daily for 7–10 days (e.g., cellulitis, abscesses requiring coverage of β-lactamase producers)
Urinary Tract Infections (Uncomplicated)	625 mg twice daily for 7 days (adjust for renal impairment as needed)
Diabetic Foot Infections	625 mg three times daily for 10–14 days (adjunct to debridement and offloading measures)

Administration: Swallow Augmentin Duo 625 mg whole with water within 30 minutes of meal to enhance absorption and minimize gastrointestinal upset.
Missed Dose: If a dose is missed, take it as soon as possible. Do not take two doses simultaneously; maintain at least 4 hours between doses.
Complete Course: Finish the entire prescribed course to prevent resistance and ensure infection eradication.

⚠️ Warnings & Side Effects

Common Side Effects (≥1%):

Gastrointestinal: Diarrhea, nausea, vomiting, dyspepsia
Skin: Rash, urticaria

Less Common:

Transient elevated liver enzymes (AST/ALT)
Vaginal candidiasis (thrush), candidal overgrowth

Serious (Rare):

Clostridioides difficile–associated diarrhea (CDAD)
Severe hypersensitivity reactions (anaphylaxis, Stevens–Johnson syndrome)
Hepatic dysfunction, cholestatic jaundice

Precautions:

Allergy: Contraindicated in patients with history of penicillin or β-lactamase inhibitor hypersensitivity.
Hepatic Impairment: Use with caution; monitor liver function tests, particularly in patients with cholestatic diseases.
Renal Impairment: Dose adjustment recommended for creatinine clearance <30 mL/min; extend dosing interval or reduce dose based on GFR.
Pregnancy & Lactation: Category B; use only if clearly needed. Excreted into breast milk; monitor nursing infants for diarrhea or fungal infections.
Pediatric Use: Approved in children ≥3 months; follow weight-based dosing guidelines.

🏥 Storage Instructions

Store Augmentin Duo 625 mg tablets at 20–25°C (68–77°F). Protect from moisture and excessive heat. Keep tablets in original strip until use. Discard any expired tablets. Keep out of reach of children.

🌐 Availability & Purchasing

United States: Prescription required; branded as Augmentin, available in multiple strengths including 875/125 mg and 500/125 mg; 625 mg is less common but available via prescription.
United Kingdom & EU: Prescription-only; generic amoxicillin/clavulanate formulations available.
Australia: TGA-approved; prescription necessary; available as generics under various brand names.

Importing Augmentin Duo 625 mg from India:
Purchasing Augmentin Duo from India can offer cost savings. Ensure compliance with local import regulations, maintain a valid prescription, and verify product authenticity through batch certification to avoid counterfeit medications.

🔗 Internal Links to Authoritative Resources

🔗 Antibiotic Therapies (Indian Brands)

Cefdinir 300 mg (Sefdin) – Oral third-generation cephalosporin by Unichem for CAP and skin infections.
Azithromycin 500 mg (Azithral) – Macrolide antibiotic by Alembic for pneumonia, sinusitis, and STIs.
Ciprofloxacin 500 mg – Fluoroquinolone by Cipla for UTIs and gastrointestinal infections.

🎥 Educational Video on Amoxicillin/Clavulanate Therapy

👨‍⚕️ Expert Insight: Dr. Vandana Mehta, Infectious Disease Specialist

“Augmentin Duo 625 mg is ideal for moderate-to-severe infections where β-lactamase–producing organisms are suspected. Administer with food to reduce gastrointestinal upset and monitor renal function in at-risk populations.”