โ Active Ingredient Overview Table:
| ๐ฌ Active Ingredient (Generic Name): | Clindamycin Phosphate |
|---|---|
| ๐ Indication: | Acne Vulgaris (Inflammatory Lesions) |
| ๐บ๐ธ US Brand: | Cleocin T, Clindagel |
| ๐ญ Manufacturer: | Galderma India Pvt Ltd (Founded: 1981) |
| ๐ฆ Packaging: | 15 g Tube |
| ๐งช Strength: | 1% (w/w) Clindamycin Phosphate |
| ๐ Delivery Time: | 6โ15 days |
๐ฟ What is Clindac A Gel 1% (Clindamycin)?
Clindac A Gel contains 1% clindamycin phosphate, a lincosamide antibiotic formulated for topical application in acne management. It penetrates pilosebaceous units to inhibit Propionibacterium acnes protein synthesis, reducing inflammatory lesion counts and preventing new pustules and papules.
Inflammatory acne arises from bacterial colonization and subsequent immune response. By applying Clindac A Gel twice daily, patients can achieve a significant reduction in lesion count within 4โ6 weeks, improving both clinical signs and patient confidence.
๐งฌ Pharmacology & Mechanism of Action
| Attribute | Detail |
|---|---|
| Chemical Formula | C18H33ClN2O8P |
| Molecular Weight | 515.98 g/mol |
| Bioavailability | Low systemic absorption (<2%) |
| Metabolism | Hepatic |
| Half-Life | ~2 hours (systemic) |
Topical clindamycin disrupts bacterial protein synthesis by binding the 50S ribosomal subunit, leading to bacteriostatic effects against P. acnes and Staphylococcus epidermidis.
๐ก Indications & Application
| Condition | Application |
|---|---|
| Inflammatory Acne Vulgaris | Apply a thin film to affected areas twice daily after cleansing; use for at least 12 weeks |
Avoid contact with eyes and mucous membranes. Do not use occlusive dressings.
โ ๏ธ Warnings & Side Effects
Common:
- Dryness, peeling
- Itching, erythema
Serious (rare):
- Allergic contact dermatitis
- Clostridium difficileโassociated diarrhea (with systemic absorption)
Use caution in patients with a history of antibiotic-associated colitis. Discontinue if severe local irritation or hypersensitivity occurs.
๐ฅ Storage Instructions
Store Clindac A Gel at 20โ25ยฐC. Protect from light. Keep cap tightly closed and out of reach of children.
๐ Availability & Purchasing
- USA: Prescription-only (Cleocin T, Clindagel). Generic topical clindamycin available.
- UK & EU: Prescription required; widely accessible topical formulations.
- Australia: Prescription and TGA approval necessary.
Importing from India can reduce costs; ensure compliance with local regulations.
๐ Related Topical Acne Therapies
- Benzac AC 5% โ benzoyl peroxide topical.
- Epiduo Gel โ adapalene/benzoyl peroxide combination.
- Faceclin Gel โ clindamycin nicotinate topical.
๐ฅ Educational Video on Topical Acne Management
๐จโโ๏ธ Expert Insight: Dr. Neha Gupta, Dermatologist
โTopical clindamycin is an effective backbone therapy for inflammatory acne. Combining with benzoyl peroxide can reduce resistance and enhance efficacy.โ







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