Name: Dapsone
SKU: 23332
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Dapsone (Diaminodiphenyl Sulfone)
💊 Indication:	Dermatitis Herpetiformis, Leprosy, Pneumocystis Jirovecii Pneumonia (PCP) Prophylaxis
🇺🇸 US Brand Equivalent:	Aczone (Topical Dapsone), Dapsone Oral Tablets (Generic)
🏭 Manufacturer:	GlaxoSmithKline Pharmaceuticals Ltd (Founded: 2000)
📦 Packaging:	1000 Tablets per Bottle
🧪 Strength:	100 mg
🚚 Delivery Time:	6–15 days

🌿 What is Dapsone 100 mg?

Dapsone is a sulfone antibiotic with anti-inflammatory properties. It is indicated for the treatment of dermatitis herpetiformis, a pruritic blistering skin condition associated with celiac disease, and multibacillary leprosy as part of combination therapy (e.g., with rifampicin and clofazimine). Additionally, Dapsone serves as prophylaxis against Pneumocystis jirovecii pneumonia (PCP) in HIV-infected patients intolerant to trimethoprim-sulfamethoxazole. Its dual antimicrobial and anti-inflammatory actions arise from inhibition of dihydropteroate synthase in microbial folate synthesis and suppression of neutrophil myeloperoxidase-derived oxidants.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Dapsone 100 mg	• Antibacterial: Inhibits dihydropteroate synthase → disrupts folate synthesis in Mycobacterium leprae and Pneumocystis jirovecii. • Anti-inflammatory: Reduces neutrophil chemotaxis and inhibition of myeloperoxidase-derived oxidant production → decreases inflammation in dermatitis herpetiformis.
Absorption	Rapid oral absorption; peak plasma concentration ~2–4 hours post-dose.
Distribution	Widely distributed; crosses blood-brain barrier; high concentrations in skin and gastrointestinal tract.
Metabolism	Hepatic N-acetylation and glucuronidation; metabolites excreted renally.
Half-Life	~20–30 hours (varies based on acetylator status).

💡 Indications & Usage

Condition	Dosage & Regimen
Dermatitis Herpetiformis	• Initial: 100 mg orally once daily. • Titrate by 50 mg increments every 1–2 weeks until rash control (max 300 mg/day divided BID). • Once controlled, taper to lowest effective dose.
Leprosy (as part of ROM therapy or WHO MDT)	• Multibacillary regimen: 100 mg orally once daily as part of combination with rifampicin (600 mg monthly) and clofazimine (300 mg monthly, then 50 mg daily). • Duration per WHO guidelines: 12 months.
PCP Prophylaxis in HIV-Infected Patients	• 100 mg orally once daily. • If intolerance to daily dosing, 200 mg orally three times weekly can be used. • Monitor for hemolysis; consider folinic acid supplementation if needed.

Administration Tips:

Take with food to reduce gastrointestinal upset.
Divide dose into two daily administrations if >100 mg to minimize peak-related side effects.
Perform baseline G6PD testing to assess risk of hemolytic anemia.

⚠️ Warnings & Side Effects

Common Side Effects:

Gastrointestinal upset (nausea, vomiting)
Headache
Dizziness
Skin rash (mild)

Hematologic:

Hemolytic anemia (especially in G6PD-deficient patients)
Methemoglobinemia (dose-dependent; monitor for cyanosis, fatigue)
Agranulocytosis (rare; monitor CBC regularly during therapy)

Serious (Rare):

Hypersensitivity syndrome (Dapsone hypersensitivity reaction): presents with fever, rash, lymphadenopathy, hepatitis, and eosinophilia. • Onset: 4–6 weeks after initiation. • Management: Discontinue immediately; supportive care.
Neurotoxicity: peripheral neuropathy (long-term use)
Hepatotoxicity: monitor liver enzymes periodically.

Precautions:

G6PD Deficiency: Contraindicated due to high risk of severe hemolysis.
Pregnancy/Breastfeeding: Use only if potential benefit outweighs risks; crosses placenta and excreted in breast milk.
Monitoring: Baseline and periodic CBC with differential, reticulocyte count, methemoglobin levels, liver function tests.

🏥 Storage Instructions

Store Dapsone 100 mg tablets at room temperature (20°C–25°C). Protect from moisture and light. Keep bottle tightly closed in original packaging. Discard 6 months after opening. Ensure tablets remain dry and out of reach of children.

🌐 Availability & Purchasing

United States: Prescription required; Dapsone tablets available as generic. – United Kingdom & EU: Prescription-only; Dapsone indicated for dermatitis herpetiformis and leprosy. – Australia: Prescription mandatory; available through specialist clinics for dermatological and infectious indications.

Importing Dapsone 100 mg from India can provide cost savings. Ensure a valid prescription and compliance with local importation regulations (e.g., personal import schemes) to avoid customs delays.

🔗Authoritative Resources

NHS: Dermatitis Herpetiformis Overview

🔗 Internal Links to Related Antimicrobial & Dermatologic Therapies (Indian Brands)

Clofazimine 100 mg Capsules – Companion in leprosy therapy by Abbott India.

🎥 Educational Video on Dapsone Therapy

👨‍⚕️ Expert Insight: Dr. Anjali Mehta, Dermatologist & Infectious Disease Specialist

“Dapsone’s utility in both dermatologic inflammatory conditions and infectious disease prophylaxis underscores its versatility. Careful monitoring for hematologic toxicity and hypersensitivity is critical for patient safety.”