Name: Eptoin 300 mg ER
SKU: 22869
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Phenytoin
💊 Indication:	Epilepsy (Generalized & Partial Seizures), Status Epilepticus Prophylaxis
🇺🇸 US Brand:	Dilantin® Kapseals® (ER)
🏭 Manufacturer:	Abbott India Pvt. Ltd. (Founded: 1944)
📦 Packaging:	30 Extended-Release Tablets per Bottle
🧪 Strength:	300 mg
🚚 Delivery Time:	6–15 days

🌿 What is Phenytoin 300 mg ER (Eptoin ER)?

Eptoin ER provides 300 mg of Phenytoin in an extended-release formulation, ensuring stable plasma concentrations over 24 hours with once-daily dosing. This is ideal for maintenance therapy, reducing peak–trough fluctuations and improving seizure control and patient adherence.

By modulating voltage-gated sodium channels, Phenytoin decreases neuronal excitability. The ER delivery reduces gastrointestinal irritation and minimizes neurotoxic peaks compared to immediate-release formulations.

Refer to the FDA label for Dilantin® Kapseals® and the Drugs.com monograph for detailed prescribing information.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C15H12N2O
Molecular Weight	252.27 g/mol
Bioavailability	~90% (ER)
Metabolism	Hepatic (CYP2C9, CYP2C19)
Half-Life	~24 hours (dose-dependent)

Phenytoin in ER form maintains therapeutic levels with reduced risk of toxicity associated with peak concentrations.

💡 Indications & Dosing

Condition	Dose & Administration
Maintenance Therapy for Seizures	300 mg ER once daily; titrate after at least 7 days based on plasma levels and clinical response
Status Epilepticus Prophylaxis	300 mg ER daily initiated post-event as prescribed by neurologist

Maintain dosing consistency; do not crush or chew. Monitor plasma levels to maintain 10–20 µg/mL.

⚠️ Warnings & Side Effects

Common:

Dizziness, ataxia
Gingival hyperplasia
Nystagmus

Serious:

SJS/TEN (HLA-B*1502 risk)
Blood dyscrasias
Hepatotoxicity

Screen ethnically at-risk patients for HLA-B*1502. Monitor CBC, LFTs, and levels. Educate on oral hygiene to reduce gingival issues.

🏥 Storage Instructions

Store Eptoin ER 300 mg at 20–25°C in original bottle. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Dilantin® Kapseals®); branded ER available.
UK & EU: Prescription required; ER phenytoin formulations limited.
Australia: Prescription and TGA approval required.

Importing from India may reduce cost; ensure compliance with local regulations and maintain valid prescription.

🔗 Related Antiepileptic Regimens

Eptoin 100 mg – immediate-release formulation.
Lamotrigine 100 mg – adjunct therapy.

🎥 Educational Video on Extended-Release Phenytoin

👨‍⚕️ Expert Insight: Dr. Neeta Sharma, Neurologist

“Eptoin ER simplifies seizure management with the convenience of once-daily dosing, improving compliance and reducing the risk of breakthrough seizures due to missed doses.”