📋 Product Overview Table
| 🌐 Specification | 🧾 Details |
|---|---|
| 💊 Active Ingredient | Estradiol Valerate 10mg |
| 🏭 Manufacturer | Actiza Pharmaceutical Pvt. Ltd., India |
| 💉 Dosage Form | Injectable Solution (Depot Form) |
| 📦 Packaging | 10 x 1ml ampoules per box |
| 🩺 Indication | Hormone Replacement Therapy, Estrogen Deficiency, HRT, ART |
| 🇺🇸 US Brand Equivalent | Delestrogen (Estradiol Valerate Injection) |
| ⏱️ Delivery Time | 6 to 15 business days |
🧬 Introduction – What is Estraval Depot 10mg?
Estraval Depot 10mg, manufactured by Actiza Pharmaceutical Pvt. Ltd., is a long-acting injectable estrogen preparation that contains Estradiol Valerate, a synthetic estrogen ester. This medication is used for Hormone Replacement Therapy (HRT) in women experiencing menopausal symptoms or estrogen deficiency, and in Assisted Reproductive Technologies (ART) to prepare the endometrium.
Administered intramuscularly, this depot injection ensures slow and sustained release, making it convenient for patients requiring long-term hormonal therapy.
This injectable solution is a viable alternative to oral estrogens for those who experience GI issues or prefer less frequent dosing schedules.
🎥 Educational Video – Understanding Depot Estrogen Injections
📺 “What is Estradiol Valerate Injection Used For?”
🎬 Video Placeholder – Learn how long-acting estrogen injections function in menopause and fertility care.
⚠️ Injectable estrogens must be administered under professional medical supervision.
🔬 Mechanism of Action
| ⚗️ Component | 🔍 Pharmacodynamics |
|---|---|
| Estradiol Valerate 10mg | Slowly hydrolyzed to estradiol, binds to estrogen receptors, regulates target tissue activity |
- Reduces vasomotor symptoms of menopause
- Supports endometrial growth for embryo transfer
- Assists in the management of hypogonadism or ovarian failure
💡 Dosing & Administration
| 📋 Indication | 💉 Typical Dosage |
|---|---|
| Hormone Replacement Therapy | 10–20mg IM every 4 weeks |
| Estrogen Deficiency (Hypogonadism) | 10mg IM every 2–4 weeks |
| ART / IVF Endometrial Preparation | 10mg IM as directed in protocol |
Administer via deep intramuscular injection only. Dose varies based on indication.
⚠️ Side Effects & Contraindications
| 💥 Common Reactions | ❗ Serious Risks |
|---|---|
| Breast tenderness, headache | Deep vein thrombosis, stroke, endometrial cancer |
| Nausea, injection site pain | Liver dysfunction, gallbladder disease |
| Water retention, mood swings | Estrogen-dependent neoplasia |
Contraindications:
- Pregnancy
- History of thromboembolic disease
- Estrogen-sensitive cancers
🧃 Storage Instructions
- Store below 25°C
- Do not freeze
- Protect from light
- Keep out of reach of children
🌍 Availability & Import Rules
| 🌎 Region | 🚚 Import Eligibility | 📋 Prescription Required |
|---|---|---|
| 🇺🇸 USA | Permitted under FDA personal import policy | ✅ Yes |
| 🇬🇧 UK | Allowed under MHRA guidelines | ✅ Yes |
| 🇦🇺 Australia | Personal import scheme accepted by TGA | ✅ Yes |
Delivery estimate: 6–15 working days via trusted Indian exporters.
🔗 Related Hormonal Medications (Internal Links)
| 💊 Product | 🏭 Manufacturer | 📖 Description |
|---|---|---|
| Progynova 2mg | Zydus Healthcare | Oral estrogen therapy for menopause and IVF |
| Duphaston 10mg | Abbott India | Progestogen used in endometrial protection and HRT |
| Susten 200mg | Sun Pharma | Natural progesterone used in luteal phase and pregnancy support |
| Cabgolin 0.5mg | Sun Pharma | For prolactin-related menstrual disorders |
| Deviry 10mg | Medley Pharma | Regulates menstrual cycle, supports HRT |
📚 References & External Resources
- Drugs.com – Estradiol Valerate Injection
- PubMed – Injectable Estrogen Therapies
- NHS – Estrogen Use in Women
- Actiza Pharma – Official Website
- TGA – Importing Medications
🩺 Expert Review – Dr. Rachita Mehra, MD (Reproductive Endocrinology)
“Estraval Depot 10mg is an effective injectable estrogen that provides a steady hormone level over weeks. It is ideal for women preferring less frequent administration or those in advanced fertility treatment protocols.”
⚠️ Disclaimer
This article is intended for informational purposes only. Always consult a licensed healthcare provider before using any hormone replacement therapy like Estraval Depot.




