Fluconazole

Fluconazole

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Fluconazole
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✅ Reviewed by Dr. Robert Mitchell, PharmD— Clinical Pharmacist & Medical Writer

🧾 Product Overview

Parameter Details
Brand / Generic Fluconazole (Generic Diflucan)
Manufacturer Kachhela Medex Pvt. Ltd. (India)
Active Ingredient Fluconazole
Strengths 100 mg • 150 mg • 200 mg
Dosage Form Oral tablets
Packaging 10 tablets per strip
Therapeutic Class Antifungal (Azole)
Delivery Time Australia 6–12 days • US/UK/EU 8–18 days

💊 Indications & Uses

Fluconazole is indicated for a wide range of fungal infections. Its broad-spectrum activity makes it a versatile treatment option:

🩺

Vaginal Candidiasis

Often treated with a single 150mg dose — convenient and highly effective.

🦷

Oral & Esophageal Thrush

Common in immunocompromised patients — typically 100–200mg daily for 7–14 days.

🧴

Dermatophytosis

Ringworm, athlete’s foot, and jock itch respond well to oral fluconazole.

🧠

Cryptococcal Meningitis

200–400mg daily under specialist supervision for severe systemic infections.

🧠 How Fluconazole Works

Fluconazole targets a key enzyme called lanosterol 14α-demethylase, which is essential for the production of ergosterol — a critical component of fungal cell membranes. By blocking this enzyme, the drug disrupts cell membrane integrity, causing fungal cells to become leaky and eventually die.

This mechanism makes fluconazole particularly effective against Candida albicans and Cryptococcus neoformans — two of the most common fungal pathogens in clinical practice.

💉 Dosage & Administration

Condition Typical Dose Duration
Vaginal Candidiasis 150 mg single dose Single-day therapy
Oropharyngeal Candidiasis 100–200 mg daily 7–14 days
Esophageal Candidiasis 200–400 mg daily 14–21 days
Cryptococcal Meningitis 200–400 mg daily Weeks–months (specialist)

📌 Important: The 150mg tablet is the standard single-dose treatment for vaginal yeast infections — a convenient option that eliminates the need for multi-day courses.

⚠️ Side Effects & Warnings

😟

Common Side Effects

Nausea, abdominal pain, diarrhea, headache — usually mild and temporary.

🚨

Serious Risks

Liver enzyme elevation, QT prolongation, severe skin reactions — require monitoring and immediate medical attention.

⚠️

Drug Interactions

Significant CYP450 interactions — especially with warfarin, phenytoin, and sulfonylureas.

⚠️ Critical Warning: Fluconazole should be used with caution in pregnancy and only when the benefits outweigh the risks. Liver function tests should be monitored during prolonged therapy.

🌍 Global Shipping & Availability

Region Availability Delivery Time
🇦🇺 Australia Priority stock 6–12 days
🇺🇸 USA Available 8–18 days
🇬🇧 UK Available 8–15 days
🇪🇺 EU Varies by country 10–20 days

🔗 Antifungal Products

💊

Zocon Eye Drops

Fluconazole 0.3% by FDC Ltd

View Product →

👨‍⚕️ Doctor’s Expert Opinion

“Fluconazole remains a first-line oral antifungal for many Candida infections — especially vaginal and oropharyngeal candidiasis. The 150mg single-dose regimen is a particular standout for its convenience and high cure rates. Quality generics like those from Kachhela Medex offer effective therapy at a lower cost, making treatment more accessible. However, clinicians should always monitor for liver function abnormalities and drug interactions, particularly in patients on multiple medications.”

Dr. N. Verma, Infectious Disease Specialist

❓ Frequently Asked Questions

What is fluconazole used for?

Fluconazole is used to treat vaginal yeast infections, oral thrush, esophageal candidiasis, ringworm, athlete’s foot, and systemic fungal infections like cryptococcal meningitis.

What is the recommended dose for a yeast infection?

For vaginal candidiasis, the typical dose is a single 150mg tablet. This single-dose therapy is convenient and highly effective.

What are the common side effects of fluconazole?

Common side effects include nausea, abdominal pain, diarrhea, and headache. These are usually mild and temporary. Serious side effects like liver damage are rare but require monitoring.

Can fluconazole be taken during pregnancy?

Fluconazole should be used during pregnancy only when clearly needed and under strict medical supervision. High doses have been associated with congenital abnormalities.

Is fluconazole the same as Diflucan?

Yes. Diflucan is the brand name for fluconazole. Generic versions like those from Kachhela Medex contain the same active ingredient and are therapeutically equivalent.

📚 References & Resources

Additional Information

Strength

100mg, 150mg, 200mg

Tablets

30, 60, 90

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