🧠 Dimethyl Fumarate 120 mg & 240 mg (Sclerifuma) — Generic Tecfidera by Sun Pharma

Name: Generic Tecfidera
SKU: 26916
Availability: InStock

Oral disease-modifying therapy for relapsing multiple sclerosis • Starter 120 mg & maintenance 240 mg • 10 capsules per strip • Worldwide delivery via BuyAllMD

Dimethyl Fumarate 120 mg / 240 mg (brand Sclerifuma) by
Sun Pharmaceutical Industries Ltd is an oral disease-modifying therapy (DMT) for adults with
relapsing forms of multiple sclerosis (RMS).
It is a generic equivalent of Tecfidera® (dimethyl fumarate), a well-established MS medication used to
reduce relapse frequency, slow disability progression, and limit new MRI lesion activity when taken long-term under specialist supervision.

🧾 Product Overview

Brand Name	Sclerifuma
Generic / Active Ingredient	Dimethyl Fumarate (DMF)
Available Strengths	120 mg & 240 mg delayed-release capsules
Dosage Form	Oral, delayed-release hard gelatin capsules
Manufacturer	Sun Pharmaceutical Industries Ltd (India)
Packaging	10 capsules per strip (starter and maintenance packs)
Reference Brand	Tecfidera® (dimethyl fumarate) by Biogen
Indication	Relapsing forms of multiple sclerosis (RMS) in adults, as per neurologist’s prescription
Estimated Delivery	Australia 6–12 days • USA 8–18 days • UK/EU 10–20 days

🧬 How Dimethyl Fumarate Works in Multiple Sclerosis

Dimethyl fumarate is thought to exert its MS-modifying effect mainly through:

Nrf2 pathway activation: DMF and its active metabolite monomethyl fumarate activate the nuclear factor (erythroid-derived 2)–like 2 (Nrf2) pathway,
up-regulating antioxidant and cytoprotective genes that help defend CNS cells against oxidative stress.
Immunomodulation: It shifts immune responses away from pro-inflammatory Th1/Th17 profiles toward a more anti-inflammatory phenotype and reduces circulating lymphocyte counts,
thereby dampening autoimmune attacks on myelin.
Neuroprotection: Experimental data suggest potential protection of neurons and glial cells from inflammatory and oxidative damage, which may contribute to reduced lesion activity and slower disability progression.

🎯 Indications & Clinical Goals

Relapsing forms of multiple sclerosis (RMS) in adults, including:
- Relapsing–remitting MS (RRMS)
- Active secondary progressive MS with relapses, where permitted by guidelines
Prescribed by neurologists as a long-term disease-modifying therapy to:
- Reduce the annualised relapse rate
- Lower MRI lesion burden (new/enlarging T2, gadolinium-enhancing lesions)
- Delay accumulation of disability over time

Dimethyl fumarate is not used for acute MS relapses (where high-dose steroids are preferred) and does not cure MS — it is a long-term control strategy.

💊 Dosage & Titration (Adult RMS)

Sclerifuma follows the standard Tecfidera-style dose escalation, using both 120 mg and 240 mg strengths. Exact regimen must always follow your neurologist’s prescription.

Treatment Phase	Strength Used	Typical Dose	Duration / Notes
Initial titration (Week 1)	120 mg capsules	120 mg twice daily	Used to improve GI tolerability and reduce flushing when starting therapy.
Maintenance dose (from Week 2 onward)	240 mg capsules	240 mg twice daily (total 480 mg/day)	Long-term disease-modifying dose, adjusted only under specialist guidance.
If GI or flushing issues occur	120 mg / 240 mg	Dose adjustments as per neurologist	Doctors may recommend temporary down-titration or administration with food.

💡 Administration: Swallow capsules whole; do not crush, chew, or open them. Taking with food can help reduce flushing and stomach upset. Do not change dose without specialist approval.

📊 Monitoring: Blood Counts & Infection Risk

Dimethyl fumarate affects the immune system and requires regular safety monitoring:

Complete blood count (CBC) with lymphocyte count at baseline, then periodically (e.g. every 3–6 months) to watch for lymphopenia.
Liver function tests at baseline and periodically.
Ongoing assessment for opportunistic infections or unusual neurological symptoms that could indicate rare complications such as
progressive multifocal leukoencephalopathy (PML) in the presence of severe, prolonged lymphopenia.
Vaccination status and infection history should be reviewed before starting therapy.

✅ Potential Benefits of Sclerifuma (Dimethyl Fumarate)

Oral dosing: Capsule-based DMT avoids injections and infusions, which many patients find more convenient.
Proven efficacy: Dimethyl fumarate has been shown in trials to reduce relapse rates and MRI activity and to slow disability progression in RMS when used continuously.
Established safety data: Tecfidera-class experience over many years has clarified key risk factors and monitoring strategies.
Indian generic by Sun Pharma: Sclerifuma offers a potentially more cost-effective alternative to originator brands, which is important for long-term therapy adherence.

⚠️ Side Effects & Safety Considerations

Like other MS DMTs, dimethyl fumarate can cause side effects ranging from mild and transient to serious. Patients must be counselled and monitored appropriately.

Very common / common:
- Flushing (warmth, redness, itching, burning)
- Gastrointestinal symptoms: nausea, diarrhoea, abdominal pain, vomiting, dyspepsia
- Headache, fatigue
Laboratory: decreased lymphocyte counts, elevated liver enzymes.
Serious but rare:
- Severe, prolonged lymphopenia leading to heightened infection risk
- Progressive multifocal leukoencephalopathy (PML) — a rare, life-threatening brain infection linked to profound immunosuppression
- Severe allergic reactions, serious liver injury

Seek urgent medical attention for unusual infections, persistent fever, extreme tiredness, personality or cognitive changes, vision problems, weakness, or seizures.
These may represent serious complications that must be evaluated immediately by an MS specialist.

👨‍⚕️ Neurologist’s Expert Opinion

“Dimethyl fumarate remains one of the core oral therapies for relapsing forms of multiple sclerosis.
For many adults it offers a good balance between efficacy, convenience, and long-term safety, provided we follow tight monitoring of lymphocyte counts and infection risk.
Patients need to understand that MS treatment is a marathon, not a sprint — adherence over years, plus lifestyle optimisation and MRI follow-up, are just as important as the choice of DMT.”
— Dr. L. Romano, Consultant Neurologist (MS Specialist)

🌱 Living with MS on Dimethyl Fumarate

Do not stop or change your MS DMT without discussing it with your neurologist.
Keep a relapse diary and bring it to your clinic visits.
Support MS therapy with exercise, smoking cessation, healthy weight, vitamin D optimisation, and good sleep where possible.
Stay up to date with vaccinations as recommended by your specialist (often before starting immunomodulating therapy).
Consider joining an MS support group for practical and emotional support.

🌍 Global Shipping & Availability via BuyAllMD

Region	Dimethyl Fumarate Availability	Estimated Delivery
Australia	Sclerifuma 120 mg & 240 mg (Sun Pharma) — RMS scripts prioritised	6–12 days*
USA	Available as Indian generic Tecfidera alternative (Rx import only)	8–18 days*
UK / EU	Supplied as generic dimethyl fumarate; local MS and import rules apply	10–20 days*

*Transit times are indicative and may vary due to customs processing, routing, or public holidays.

🔗 Related Neurology & Immune Modulating Medicines on BuyAllMD

Product	Main Use	Class	Product Page
Pregabalin 75 mg	Neuropathic pain, fibromyalgia, partial seizures	Anticonvulsant / neuropathic pain agent	Pregabalin
Gabapentin 300 mg	Neuropathic pain, seizures	Anticonvulsant	Gabapentin
Methylprednisolone 1 g IV (vial)	Acute MS relapses & severe inflammatory flares	High-dose corticosteroid (hospital use)	Methylprednisolone

📚 External Medical References (Dimethyl Fumarate / Tecfidera)

🩺 Medical & Legal Disclaimer

This article is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment.
Dimethyl fumarate is a prescription-only disease-modifying therapy for multiple sclerosis and must be started, adjusted, and monitored only by a neurologist or appropriately trained specialist.
Regular blood tests, MRI monitoring, and clinic visits are essential to manage benefits and risks (including infections, lymphopenia, and rare PML).
Never start, stop, or switch MS treatments on your own.
BuyAllMD supplies Indian-manufactured medicines with discreet international delivery; compliance with your country’s prescription requirements, MS treatment guidelines, and import laws remains the buyer’s responsibility.