Glibenclamide/Metformin

1. Introduction to Glibenclamide/Metformin: A Dual Diabetes Therapy

The combination of Glibenclamide (a sulfonylurea) and Metformin (a biguanide) is a popular treatment for type 2 diabetes. This dual-action therapy targets both insulin secretion and glucose production, offering enhanced glycemic control.

Key Benefits:

• Reduces insulin resistance.
• Lowers A1C levels more effectively than monotherapy.
• Available as a fixed-dose combination (FDC) or separate tablets.

👉 Read more about Metformin and Glibenclamide separately.

2. Active Ingredients: Chemistry and Mechanism

• Glibenclamide (C22H25ClN4O3S): Stimulates insulin secretion from pancreatic β-cells.
• Metformin (C4H11N5·HCl): Inhibits liver glucose production and improves insulin sensitivity.

Synergy:

• Glibenclamide addresses insulin deficiency.
• Metformin targets hepatic glucose overproduction.

🔗 FDA Glibenclamide Monograph

3. Buying Glibenclamide/Metformin in the USA

In the U.S., the combination is available as:

• Brand: Glucovance (Pfizer, founded 1849).
• Generic: Starts at $20/month (varies by dosage).

Steps to Purchase:

1. Obtain a prescription from a healthcare provider.
2. Compare prices via GoodRx or Mint Health .
3. Opt for 90-day supplies for cost savings.

👉 Explore Sitagliptin for alternative therapies.

4. UK and NHS: Availability and Costs

The NHS covers Glibenclamide/Metformin FDCs. Prices:

• Generic: £10–£20/month .
• Glucovance: £30–£50/month .

Important Notes:

• Prescriptions are valid for 2 years.
• Switching between brands may require a new prescription.

🔗 NHS Diabetes Medication Guide

5. Australia: PBS-Subsidized Options

Under Australia’s PBS, the combination costs $6.50/month for generics. Brand versions like Glucovance are available but cost more. A prescription is required.

Tip: Use the Medicare Online Script Service for digital prescriptions.

6. Importing from India: Brands and Manufacturers

Indian manufacturers such as Sun Pharma (1983) and Cipla (1935) offer affordable generics. Key options:

Import Rules:

• Limit to personal use (up to 3 months’ supply).
• Declare medications to customs.

7. Dosage and Administration

• Standard Dose:
  • Glibenclamide: 2.5–10 mg/day.
  • Metformin: 500–2000 mg/day.
• FDC Options: Combined tablets (e.g., 2.5 mg Glibenclamide + 500 mg Metformin).
• Side Effects: Hypoglycemia, nausea, metallic taste.

Storage: Keep at room temperature (15–30°C). Avoid moisture.

🔗 Drugs.com Side Effects

8. Legal Considerations: Prescription Requirements

Glibenclamide/Metformin is prescription-only globally. Purchasing without a prescription may violate regulations. Always consult a doctor before use.

9. Alternatives and Complementary Medications

• For insulin resistance: Pioglitazone (thiazolidinedione).
• For heart health: Atorvastatin (cholesterol control).

👉 Compare Linagliptin for DPP-4 inhibitor therapy.

10. Global Pricing Comparison

11. Safety Tips and Storage

• Monitor blood sugar levels regularly to prevent hypoglycemia.
• Avoid alcohol, as it increases hypoglycemia risk.
• Store in a cool, dry place.

Conclusion

The Glibenclamide/Metformin combination is a powerful tool for managing type 2 diabetes. By understanding regional pricing, legal requirements, and proper use, patients can optimize their treatment while minimizing risks.

Final Advice: Always verify drug information with WHO Guidelines and consult a healthcare professional.