Ketorol Injection

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Ketorol Injection
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Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name): Ketorolac Tromethamine
💊 Indication: Short-Term Management of Moderate to Severe Pain (Acute Postoperative Pain)
🇺🇸 US Brand: Toradol
🏭 Manufacturer: Dr. Reddy’s Laboratories Ltd (Founded: 1984)
📦 Packaging: 1 mL ampoule (30 mg/mL) per Pack of 5
🧪 Strength: 30 mg/mL
🚚 Delivery Time: 6–15 days

🌿 What is Ketorolac 30 mg/mL Injection (Ketorol)?

Ketorol 30 mg/mL injection contains Ketorolac Tromethamine, a potent nonsteroidal anti-inflammatory drug (NSAID) approved for short-term management of moderate to severe acute pain. It works by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis and pain signaling.

For comprehensive prescribing details, safety information, and contraindications, consult the FDA label for Toradol, the Drugs.com monograph, the NHS Medicines A–Z entry, and the WHO Essential Medicines List.


🧬 Pharmacology & Mechanism of Action

Attribute Detail
Chemical Formula C15H13NO3
Molecular Weight 255.27 g/mol
Bioavailability 100% (IV/IM)
Metabolism Hepatic (CYP2C9)
Half-Life ~5–6 hours

Ketorolac’s COX inhibition provides effective analgesia equivalent to moderate-dose opioids in acute settings, without opioid side effects.


💡 Indications & Dosing

Condition Dose & Administration
Acute Moderate to Severe Pain (Adult) 30 mg IV or IM every 6 hours as needed, not to exceed 120 mg/day or 5 days duration

Avoid initiation in patients ≥65 years or with renal impairment without dose adjustment. Maximum treatment duration is 5 days.


⚠️ Warnings & Side Effects

Common:

  • GI upset (nausea, dyspepsia)
  • Injection site pain
  • Headache, dizziness

Serious:

  • GI bleeding, ulceration
  • Renal impairment, acute kidney injury
  • Cardiovascular events (MI, stroke)

Contraindicated in active peptic ulcer disease, recent GI bleeding, advanced renal disease, and perioperative pain in CABG surgery. Monitor renal function and signs of bleeding.


🏥 Storage & Preparation

Store at 15–30°C. Protect from light. Inspect ampoule for particulate matter; administer via IV push over at least 15 seconds or deep IM injection.


🌐 Availability & Purchasing

  • USA: Prescription-only (Toradol); IV/IM forms.
  • UK & EU: Prescription required; Ketorolac injection available.
  • Australia: Prescription and TGA approval needed.

Importing from India may offer cost savings; ensure adherence to regulatory requirements and valid prescription.


🎥 Educational Video on Ketorolac Use


👩‍⚕️ Expert Insight: Dr. Rahul Mehta, Anesthesiologist

“Ketorolac 30 mg injection is an essential component of multimodal analgesia, reducing opioid requirements and improving postoperative pain control with a favorable safety profile when used short term.”


Additional Information

Active

Ketorolac

Injection/s

5, 10, 15

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