| 🔬 Active Ingredient (Generic Name): | Mebeverine Hydrochloride |
| 💊 Indication: | Irritable Bowel Syndrome, Gastrointestinal Spasms |
| 🇺🇸 US Brand: | Colofac |
| 🏭 Manufacturer: | Dr. Reddy’s Laboratories Ltd. (Founded: 1984) |
| 📦 Packaging: | 10 Tablets per Strip |
| 🧪 Strength: | 135 mg |
| 🚚 Delivery Time: | 6–15 days |
🌿 What is Mebeverine 135 mg (Morease)?
Morease contains Mebeverine, a smooth muscle relaxant active in the gastrointestinal tract. It blocks calcium channels in intestinal smooth muscle, reducing spasm, pain, and discomfort associated with irritable bowel syndrome (IBS) and other functional bowel disorders.
Clinically, Morease is shown to alleviate abdominal cramps and bloating within 30–45 minutes, helping patients resume daily activities quickly. Moreover, its gut-specific action means it does not interfere with normal gastric secretions or motility. As a result, Morease offers effective symptom control without common NSAID-related risks.
For detailed prescribing information, refer to the FDA label for Colofac and safety profile on Drugs.com. Additional guidance is available via the NHS Medicines A–Z and the WHO Model Formulary.
🧬 Chemical Composition & Mechanism
| Attribute | Detail |
| Chemical Formula | C20H21N3O4 |
| Molecular Weight | 359.40 g/mol |
| Bioavailability | ~90% |
| Metabolism | Hepatic |
| Half-Life | ~2 hours |
Mebeverine acts locally on gut muscle to relieve cramps without affecting normal motility or gastric secretion.
💡 Indications & Usage
- Irritable Bowel Syndrome (IBS): 135 mg three times daily, before meals.
- Gastrointestinal Spasms: Relieves colic, bloating, and abdominal pain.
💊 Dosage & Administration
| Condition | Dosage |
| IBS & Spasms | 135 mg three times daily (before meals) |
Swallow tablets whole with water. Do not crush or chew.
⚠️ Warnings & Side Effects
Common:
- Mild headache
- Flushing
- Nausea
Rare:
- Allergic reactions (rash, itching)
- Dizziness
Use with caution in patients with severe hepatic or renal impairment.
🏥 Storage Instructions
Store at 20–25°C, protect from moisture. Keep out of reach of children.
🌐 Availability & Purchasing
- USA: Available as Colofac; prescription required.
- UK & Europe: Over-the-counter or prescription depending on country.
- Australia: Prescription required; TGA approval needed for import.
Importing from India offers cost savings; ensure local compliance and valid prescription.
🔗 Related Gastrointestinal Therapies
- Duspatalin (Mebeverine) 135 mg SR by Abbott.
- Buscopan (Hyoscine Butylbromide) 10 mg for cramp relief.
- Iberogast – herbal gut relaxant.
- Linaclotide – for IBS-C.
- Loperamide 2 mg – antidiarrheal.
🎥 Educational Video on Mebeverine
👨⚕️ Expert Insight: Dr. Shalini Rao, Gastroenterologist
“Mebeverine is an effective antispasmodic for IBS, offering symptom relief without significant side effects or alteration of normal gut function.”





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