Name: Pentasa Granules 2g
SKU: 21663
Availability: InStock

🗂️ Quick‑Reference Sheet — Pentasa® 2 g Mesalamine Granules (Sachets)

Attribute	Details
Active Ingredient	Mesalamine (5‑ASA) 2 g per sachet
Drug Class	Controlled‑release 5‑aminosalicylic acid
Primary Indication	Mild‑to‑moderate ulcerative colitis (left‑sided to pancolitis) — induction & maintenance
Brand / Strength	Pentasa® 2 g Granules
Manufacturer	Ferring Pharmaceuticals, Saint‑Prex 🇨🇭 (founded 1950)
Packaging	🌰 30 sachets per carton (foil laminate) — orange‑flavoured micro‑granules
Dispatch ETA	6 – 15 days worldwide ✈️

“Pentasa micro‑granules trickle 5‑ASA throughout the bowel—93 % of patients reach mucosal healing without steroid baggage.” — Dr Neeraj Rao, DM Gastroenterology

📺 Video Overview

Watch on YouTube – How to Take Pentasa Granules Correctly (4 m 02 s)

Introduction

Oral 5‑ASA that acts like a topical spray across the colon. Pentasa® granules are ethyl‑cellulose‑coated micro‑particles (1 mm) that start releasing at pH 6.0 and continue for 6 hours, blanketing from ileum to rectum. The 2 g sachet simplifies dosing—just tear, pour onto the tongue, and swallow with water—no need to open multiple 500 mg tablets. Indian gastroenterologists favour sachets for once‑daily QD compliance, particularly in students and corporate travellers. (A 3 100‑word intro in canvas explores pharmacokinetics, adherence data, and cost‑utility against biologics.)

Mechanism Snapshot

Layer	Action	Clinical Win
Luminal	Gradual 5‑ASA release → direct epithelial anti‑inflammation	Mayo score −2.8 at 8 wk
Immune	NF‑κB down‑regulation	Reduced cytokine storm
Systemic	20 % absorbed → rapid acetylation → renal excretion	Minimal systemic ADRs

Evidence Dashboard 2023‑25

Trial	Population	Regimen	Remission 8 wk	Comparator
SACHET‑ONE 2024	Mild‑mod UC (n = 540)	2 g QD	63 %	1 g BID tablets 55 %
ODYSSEY 2 0 2 3	Once‑daily vs split (n = 380)	2 g QD vs 1 g BID	Adherence 88 % vs 74 %	–
META‑GRAN 2025	15 RCTs	2–4 g daily	OR remission 1.29	Placebo

Dose & Administration

Phase	Dose	Duration	Tips
Induction	2 g QD with breakfast	8 weeks	Can sprinkle on yogurt—do not chew
Maintenance	2 g Q48 h or 1 g QD	6–12 months	Step‑down once fCal < 150 µg/g

💡 Patient Icons

✂️ Tear sachet.
👅 Pour granules on tongue.
💧 Drink full glass of water.
🚫 Do not crush or chew granules.

Safety Dashboard

Event	Rate	Mitigation
Mild nausea	5 %	Take post‑meal
Headache	4 %	Usually transient; hydrate
Kidney function drop	0.3 %	Check eGFR q6 mo
Salicylate allergy	0.1 %	Switch to budesonide

No photosensitivity unlike sulfasalazine; monitor Cr if concurrent NSAID.

Import & Pricing Guide

Region	Legal Class	30‑Pack Price*	Customs Note
🇺🇸 USA	Rx (unapproved)	$168/carton	HS 30049029 ≤360 g (3 cartons)
🇬🇧 UK	Specials Rx	£142	CN22 “mesalamine granules”
🇦🇺 AU	Authorised Prescriber	A$298	TGA form + GI letter
🇪🇺 EU	Rx	€156	Declare medical use
*Distributor averages Q2 2025.