Promethazine hydrochloride

Promethazine, is a widely used medication that serves various therapeutic purposes, ranging from treating allergies to managing nausea and vomiting. With its versatile applications and relatively safe profile, Phenegran can be an invaluable addition to your medicine cabinet. This article will delve into the specifics of Phenegran, including other brand names available in India, its chemical composition, side effects, dosage, and valuable information for those considering importing the medication for personal use.

What is Promethazine?

Promethazine is a first-generation antihistamine that blocks the action of histamine in the body, providing relief from allergy symptoms. Its applications extend beyond allergies, as it is also effective in preventing motion sickness, treating nausea, and as a sedative for preoperative patients. The medication works by interfering with signals in the brain that trigger vomiting, while also providing a calming effect on the central nervous system.

Brands and Manufacturers of Promethazine in India

India has a vibrant pharmaceutical industry that manufactures various formulations of Promethazine under multiple brand names. Some of the prevalent brands include:

• Phenegran (the original brand)
• Promethazine Hydrochloride
• Avil (produced by memorable manufacturers)
• Phenergan (a commonly-known brand)

Key manufacturers in India include:

• Cipla
• Sun Pharmaceutical Industries
• Dr. Reddy’s Laboratories
• Lupin Pharmaceuticals

This wide range of options ensures that consumers can find effective and accessible forms of Promethazine treatment.

Chemical Formula and Composition

The chemical formula for Promethazine is C17H20N2S. It is classified chemically as a phenothiazine derivative. Promethazine consists of an anticholinergic agent and an antihistamine agent, which work synergistically to achieve desired therapeutic effects.

Key active ingredients include Promethazine hydrochloride, while inactive ingredients may vary by formulation but may include fillers like lactose, starch, and magnesium stearate.

Dosage and Administration

The recommended dosage of Phenegran can vary depending on the condition being treated and the patient’s age. General guidelines include:

• Adults: For allergies and motion sickness, the starting dose is typically 25 mg taken one hour before travel or as needed. For nausea and vomiting, a common dose is 12.5 mg to 25 mg every 4 to 6 hours as required.
• Children: Dosages are generally half of the adult dose, starting typically from 6.25 mg to 12.5 mg.

Phenegran can be administered orally, through intramuscular injection, or as a suppository. It’s crucial to adhere to medical advice, especially for children and those with underlying health issues.

Side Effects and Warnings

While Phenegran is generally safe, several side effects may occur. Common side effects include:

• Drowsiness
• Dizziness
• Dry mouth
• Blurred vision

Serious side effects, although rare, can occur and include:

• Severe allergic reactions (rash, itching, difficulty breathing)
• Neuroleptic malignant syndrome
• Respiratory depression in pediatric patients

Patients with certain conditions (such as asthma or glaucoma) should exercise caution and consult a healthcare provider before use. Always inform a healthcare professional of other medications being taken to avoid adverse interactions.

Pricing and Availability

The price of Phenegran varies widely depending on location and formulation. In Australia, the cost of a 100 mg tablet can range from AUD 10 to AUD 30. In the USA, prices can generally average around $15 to $40 for a similar quantity. In the UK, consumers may find prices between £5 to £15.

Factors affecting these prices include formulary arrangements with pharmacies, regional pricing policies, and insurance coverage. Phenegran is widely available in pharmacies as well as online platforms.

Importing Phenegran (Promethazine) from India for Personal Use

For individuals considering importing Phenegran from India for personal use, it is vital to be aware of several legal and practical concerns:

• Legal Considerations: Each country has specific regulations regarding the importation of medications. Verify local laws regarding personal importation of prescription drugs.
• Steps to Import: Start by consulting with a healthcare provider for a proper prescription. Research reliable suppliers from India and check their shipping policies to ensure they comply with international laws.
• Potential Risks: Imported medications may vary in quality, and there is always a risk of encountering counterfeit products. It’s crucial to source from reputable manufacturers only.

In summary, Phenegran (Promethazine) is a versatile medication that effectively treats allergies, nausea, and other conditions. Understanding its applications, side effects, and the availability of various brands and manufacturers is essential for anyone considering this treatment option.

The availability of Phenegran in different countries—along with the option to import it from India—provides patients flexibility in managing their health. Always consult with healthcare professionals for personalized advice and treatment plans.