Repaglinide

1. Introduction to Repaglinide: A Meglitinide for Diabetes

Repaglinide is a meglitinide used to treat type 2 diabetes. Unlike sulfonylureas, it acts rapidly to stimulate insulin secretion in response to meals, making it ideal for patients with erratic eating patterns. Its active ingredient, repaglinide , mimics the body’s natural insulin response, lowering post-meal blood glucose effectively.

Key Features:

• Rapid-acting (starts working within 15–30 minutes).
• Requires a prescription in all major markets.
• Higher risk of hypoglycemia compared to DPP-4 inhibitors.

👉 Compare Metformin for non-insulin-dependent alternatives.

2. Repaglinide’s Active Ingredient: Chemistry and Mechanism

Repaglinide’s chemical formula is C22H29NO2S . It binds to ATP-sensitive potassium channels in pancreatic β-cells, triggering insulin release in response to rising blood glucose levels. This mechanism:

• Enhances mealtime insulin secretion.
• Reduces postprandial hyperglycemia.

Why It Stands Out:

• Flexible dosing (taken before meals, skipped if a meal is missed).
• Faster onset than sulfonylureas.

🔗 FDA Repaglinide Monograph

3. Buying Repaglinide in the USA

In the U.S., Repaglinide is available as:

• Brand: Prandin (Novo Nordisk, founded 1989).
• Generic: Starts at $100/month (varies by dosage).

Steps to Purchase:

1. Obtain a prescription from a healthcare provider.
2. Compare prices via GoodRx or Mint Health .
3. Use 90-day supplies for cost savings.

👉 Explore Sitagliptin for DPP-4 inhibitor alternatives.

4. UK and NHS: Repaglinide Availability

The NHS covers Repaglinide for eligible patients. Prices:

• Generic: £80–£120/month .
• Prandin Brand: £150–£250/month .

Important Notes:

• Prescriptions are valid for 2 years.
• Generics may require prior authorization.

🔗 NHS Diabetes Medication Guide

5. Australia: PBS-Subsidized Repaglinide

Under Australia’s PBS, Repaglinide costs $6.50/month for generics. Brand versions like Prandin are available but cost more. A prescription is required.

Tip: Use the Medicare Online Script Service for digital prescriptions.

6. Importing Repaglinide from India: Brands and Manufacturers

Indian manufacturers such as Sun Pharma (1983) and Cipla (1935) offer affordable generics. Key options:

Import Rules:

• Limit to personal use (up to 3 months’ supply).
• Declare medications to customs.

7. Dosage and Administration

• Standard Dose: 0.5–4 mg before each meal (up to 5 meals/day).
• Adjustments: Dosage varies based on blood sugar levels and renal function.
• Side Effects: Hypoglycemia, nausea, dizziness.

Storage: Keep at room temperature (15–30°C). Avoid moisture.

🔗 Drugs.com Repaglinide Side Effects

8. Legal Considerations: Prescription Requirements

Repaglinide is prescription-only globally. Purchasing it without a prescription may violate regulations. Always consult a doctor before use.

9. Alternatives and Complementary Medications

• For insulin resistance: Metformin (biguanide).
• For heart health: Atorvastatin (cholesterol control).

👉 Compare Nateglinide for another meglitinide option.

10. Global Pricing Comparison

11. Safety Tips and Storage

• Monitor blood sugar levels regularly to prevent hypoglycemia.
• Avoid alcohol, which increases hypoglycemia risk.
• Store in a cool, dry place.

Conclusion

Repaglinide is a fast-acting meglitinide that offers mealtime glycemic control for type 2 diabetes. By understanding regional pricing, legal requirements, and proper use, patients can balance efficacy and safety.

Final Advice: Always verify drug information with WHO Guidelines and consult a healthcare professional.