๐ Rifagut 200 / 400 / 550 mg (Rifaximin) โ Generic Xifaxan by Sun Pharma
Rifagut is a branded Rifaximin tablet range from
Sun Pharmaceutical Industries Ltd, one of Indiaโs largest global pharma companies.
It is widely used as a generic alternative to Xifaxanยฎ (rifaximin), the well-known gut-selective antibiotic prescribed for
travelerโs diarrhea, hepatic encephalopathy, and irritable bowel syndrome with diarrhea (IBS-D).
Unlike systemic antibiotics, rifaximin is minimally absorbed into the bloodstream and acts mostly inside the intestinal lumen, which helps
limit systemic side effects while targeting pathogenic gut bacteria.
๐งพ Product Overview
| Brand Name | Rifagut |
|---|---|
| Generic Name / Active Ingredient | Rifaximin |
| Available Strengths | 200 mg, 400 mg, 550 mg tablets :contentReference[oaicite:2]{index=2} |
| Dosage Form | Oral tablet (film-coated) |
| Manufacturer | Sun Pharmaceutical Industries Ltd (India) |
| Packaging | 10 tablets in 1 strip |
| Reference Brands | Xifaxanยฎ (USA) โข Targaxanยฎ / Xifaxantaยฎ (UK) โข Zaxineยฎ (Canada) โข Alfa Normixยฎ (EU) |
| Therapeutic Class | Non-systemic rifamycin antibiotic โข Gut-selective |
| Estimated Delivery | Australia 6โ12 days โข USA 8โ18 days โข UK/EU 10โ20 days |
๐ง How Rifaximin (Rifagut) Works
Rifaximin is a non-systemic rifamycin antibiotic that inhibits bacterial RNA synthesis by binding to the
bacterial DNA-dependent RNA polymerase.
Because it is poorly absorbed from the gut, very high local concentrations are achieved in the intestinal lumen with
limited systemic exposure. This makes Rifagut particularly useful for gut-targeted conditions such as:
- Travelerโs diarrhea due to noninvasive strains of E. coli
- Hepatic encephalopathy (HE) โ reducing ammonia-forming gut bacteria and the risk of overt HE recurrence
- Irritable Bowel Syndrome with Diarrhea (IBS-D) โ modulating the gut microbiota and bacterial overgrowth
๐ฏ Main Clinical Uses of Rifagut (Off-label indications may vary by country)
- Travelerโs diarrhea (TD) caused by noninvasive E. coli in adults.
- Hepatic encephalopathy โ reduction of recurrence risk in adults with chronic liver disease (often add-on to lactulose).
- IBS-D (Irritable bowel syndrome with diarrhea) in adults.
- Infectious/non-invasive diarrheal syndromes and gut bacterial overgrowth (where clinically appropriate and locally approved).
๐ Dosing Overview by Indication & Strength
Typical rifaximin regimens are based on the Xifaxanยฎ label and clinical guidelines; your doctor may adapt the dose and duration to your specific case.
| Indication (Adults) | Typical Strength | Dose & Frequency | Duration / Notes |
|---|---|---|---|
| Travelerโs diarrhea (TD) | Rifagut 200 mg | 200 mg three times daily | For 3 days (Xifaxan reference regimen). Not for invasive or bloody diarrhea. |
| Hepatic encephalopathy (HE) | Rifagut 550 mg | 550 mg twice daily | Chronic maintenance to reduce risk of HE recurrence; usually combined with lactulose. |
| IBS-D (Irritable bowel syndrome with diarrhea) | Rifagut 550 mg (or 400 mg where used) | 550 mg three times daily or 400 mg three times daily |
Typically 14 days per course; some patients require intermittent retreatment. |
| Non-invasive infectious diarrhea / gut dysbiosis | Rifagut 400โ550 mg | As directed by physician | Regimens differ by diagnosis, local label & protocols. |
๐ Important: Dosing for children, severe liver disease, renal impairment, and off-label uses must be individualized by a specialist. Never self-change your dose or course length.
โ Key Advantages of Rifagut (Rifaximin)
- Gut-selective action: Minimal systemic absorption compared with many oral antibiotics.
- Favourable safety profile in properly selected patients with liver disease when monitored.
- Broad activity in the intestinal lumen against E. coli and other enteric bacteria.
- Convenient oral tablet dosing โ compatible with most daily routines.
- Multiple strengths (200/400/550 mg) allow tailoring for TD, HE, IBS-D and other GI protocols.
โ ๏ธ Side Effects & Warnings
Rifaximin is generally well tolerated, but like all antibiotics it can cause adverse effects and alter the gut microbiome.
- Common: headache, flatulence, nausea, abdominal pain, fatigue.
- Possible: fever, peripheral edema, dizziness, constipation or worsening diarrhea.
- Clostridioides difficileโassociated diarrhea (CDAD) and colitis have been reported with nearly all antibiotics; any new or persistent diarrhea after treatment needs urgent medical review.
- Hypersensitivity reactions (rash, angioedema, severe skin reactions) can occur, especially with cross-sensitivity to rifampin or other rifamycins.
๐ซ Do NOT use Rifagut/Xifaxan if you have a known allergy to rifaximin, rifampin, or other rifamycin antibiotics, or if your doctor has advised against it for your liver status, pregnancy, or other medical conditions.
๐จโโ๏ธ Doctorโs Expert Opinion
travelerโs diarrhea and hepatic encephalopathy, and is increasingly used for IBS-D in selected adults.
Its major advantage is a gut-restricted antibacterial effect with low systemic absorption.
That said, it is still an antibiotic: treatment courses must be justified, monitored, and not repeated indefinitely without reassessment to
avoid resistance, microbiome disruption, or missed alternative diagnoses.โ
โ Dr. S. Kulkarni, Consultant Gastroenterologist & Hepatologist
๐ Global Shipping & Availability via BuyAllMD
| Region | Rifagut Availability | Estimated Delivery |
|---|---|---|
| Australia | All strengths (200/400/550 mg) โ priority for liver & IBS scripts | 6โ12 days* |
| USA | Available as generic Xifaxan alternative (prescription-use only) | 8โ18 days* |
| UK / EU | Shipped as Indian generic; local rules may require Rx | 10โ20 days* |
*Transit times are estimates only and can vary due to customs, routing, and public holidays.
๐ Related Gut & Liver Medications on BuyAllMD
| Product | Indication | Manufacturer | Product Page |
|---|---|---|---|
| Lactulose Syrup | Hepatic encephalopathy, constipation | Indian generics | |
| Norfloxacin 400 mg | GI & urinary bacterial infections (per label) | Multiple Indian manufacturers | Norfloxacin |
| Ofloxacin & Ornidazole Tablets | Mixed bacterial & protozoal GI infections (per label) | Indian generics | |
| Pantoprazole 40 mg | Acid reflux, gastritis, ulcer protection | Indian generics | Pantoprazole |
๐ External Medical References (Rifaximin/Xifaxan)
- Drugs.com โ Xifaxan (Rifaximin) Dosage Guide
- FDA Xifaxan Prescribing Information (Label)
- NCBI StatPearls โ Rifaximin Clinical Review
- Cleveland Clinic โ Rifaximin (Xifaxan) Uses & Side Effects
- Official Xifaxanยฎ (Rifaximin) Site โ HE & IBS-D Overview
๐ฉบ Medical & Legal Disclaimer
This article is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment.
Rifaximin (Rifagut / Xifaxan) is a prescription-only antibiotic in most countries and must be used under the supervision of a licensed healthcare professional.
Doses, indications, and treatment durations in this article are based on published sources and may not match your countryโs approved label.
BuyAllMD supplies Indian-manufactured medicines with discreet international delivery; compliance with local import, prescription, and usage laws is the buyerโs responsibility.









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