Name: Topamac 25mg
SKU: 22437
Availability: InStock

🔬 Active Ingredient (Generic Name):	Topiramate
💊 Indications:	Epilepsy (Convulsive & Nonconvulsive Seizures), Migraine Prophylaxis
🇺🇸 US Brand:	Topamax
🏭 Manufacturer:	Johnson & Johnson (Founded: 1886)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	25 mg
🚚 Delivery Time:	6–15 days

🌿 What is Topiramate 25 mg (Topamac)?

Topiramate is a broad-spectrum antiepileptic drug that enhances GABA-mediated inhibition, antagonizes AMPA/kainate glutamate receptors, and inhibits carbonic anhydrase. Topamac 25 mg tablets by J&J provide effective control of various seizure types and prevent migraine headaches.

Clinical trials indicate that topiramate significantly reduces seizure frequency and decreases migraine days by up to 50% at doses of 50–200 mg daily. Starting at 25 mg nightly and titrating upward minimizes cognitive and sedative side effects.

For complete prescribing and safety details, refer to the FDA label for Topamax and the Drugs.com monograph. Additional guidance is available via the NHS Medicines A–Z entry and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C12H21NO8S
Molecular Weight	339.36 g/mol
Bioavailability	~80%
Metabolism	Minimal hepatic (50% excreted unchanged)
Half-Life	21 hours

Topiramate’s multimodal action on neurotransmission and ion channels underlies its efficacy in epilepsy and migraine prevention.

💡 Indications & Dosing

Condition	Dose & Titration
Epilepsy (Adjunct/Monotherapy)	Start 25 mg at bedtime; increase by 25–50 mg weekly to target 100–400 mg daily in divided doses
Migraine Prophylaxis	Start 25 mg nightly; increase by 25 mg weekly to 100 mg daily (50 mg BID)

Adjust dose based on efficacy and tolerability. Renal dose adjustment required for CrCl <70 mL/min.

⚠️ Warnings & Side Effects

Common:

Paresthesia, somnolence
Cognitive impairment (memory, attention)
Weight loss

Serious (rare):

Metabolic acidosis
Glaucoma (secondary angle closure)
Suicidal ideation

Monitor bicarbonate levels, ocular symptoms, and mood changes. Use caution in patients with renal impairment.

🏥 Storage Instructions

Store at 20–25°C in original blister. Protect from moisture. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Topamax). Generic topiramate available.
UK & EU: Prescription required; generics accessible.
Australia: Prescription and TGA approval for import.

Importing from India may reduce costs; ensure compliance with regulations and valid prescription.

🔗 Related Neurological Therapies

Depakote ER (Divalproex) 125–500 mg – broad-spectrum AED.
Lamotrigine 50 mg – mood stabilizer and AED.
Levetiracetam 500 mg – adjunctive AED.
Propranolol 40 mg – migraine prophylaxis.
Topirloc 25 mg – generic topiramate.

🎥 Educational Video on Topiramate

👨‍⚕️ Expert Insight: Dr. Neeta Sharma, Neurologist

“Topiramate’s unique multi-target mechanism makes it effective for both seizures and migraine prevention. Slow titration is essential to reduce cognitive side effects.”