Name: Torinat 10mg
SKU: 24716
Availability: InStock

📋 Product Overview Table

🌐 Specification	🧾 Details
💊 Product Name	Torinat 10 mg Tablet
🧬 Active Ingredient	Everolimus (mTOR pathway inhibitor)
🏭 Manufacturer	Natco Pharma Ltd (India)
💡 Indication	Organ transplant rejection, advanced RCC, HR+ HER2– breast cancer, TSC tumors, NETs
🇺🇸 US Brand	Afinitor® / Zortress®
📦 Packaging	7 tablets per blister
🌍 Country	India
⏱️ Delivery Time	6–15 business days

🧬 Introduction

Torinat 10 mg contains everolimus, a potent mTORC1 inhibitor used for immune suppression post-transplant and as targeted therapy in advanced cancers. Produced by Natco Pharma Ltd, its applications include renal cell carcinoma, breast cancer, neuroendocrine tumors, and TSC-associated conditions (mrmed.in, dailymed.nlm.nih.gov). Its generic formulation offers affordability without compromising on clinical efficacy.

🎥 Educational Video Overview

📺 “Everolimus: From Transplants to Targeted Cancer Therapy”
🎬 Video Placeholder – covers mechanism, dosing, side effects, TDM, and patient monitoring.

💬 Reviewed by: Dr. Arjun Mehta, MD (Transplant & Oncology Specialist)

🔬 Mechanism of Action

Everolimus binds FKBP-12 and inhibits mTORC1, which results in:

T-cell proliferation suppression—preventing transplant rejection (drugs.com)
Inhibition of tumor cell proliferation in RCC, HR+ breast cancer, NETs, and TSC-related tumors (dailymed.nlm.nih.gov)

💊 Indications & Dosage

🩺 Condition	💊 Standard Dose
RCC, breast cancer, NETs, TSC	10 mg orally once daily until progression or toxicity (dailymed.nlm.nih.gov)
Transplant rejection prophylaxis	Kidney: 0.75 mg PO BID
TSC-associated SEGA in children	4.5 mg/m² once daily with trough-level monitoring

Therapeutic drug monitoring (3–8 ng/mL trough) is recommended and dosage can be adjusted based on tolerance and CYP3A4 interactions (dailymed.nlm.nih.gov).

⚠️ Side Effects & Precautions

Common Adverse Effects (≥ 30%): stomatitis, infections, rash, fatigue, diarrhea, edema
Serious Reactions: pneumonitis, nephrotoxicity, impaired wound healing, thrombocytopenia, hyperglycemia, hyperlipidemia
Precautions: monitor CBC, liver, renal, glucose, lipids; avoid live vaccines and grapefruit

🧃 Storage Instructions

Store at 15–30 °C, protect from light and moisture (drugs.com)

🔗 Indian Alternatives

💊 Medicine	🏭 Manufacturer	📝 Description
Afinitor 10 mg	Novartis	Reference brand of everolimus for oncology treatment
Zortress 1 mg	Novartis	Marketed for transplant rejection prevention
Evervéd 10 mg	Sun Pharma	Generic everolimus for oncology and transplant indications
Evorol 10 mg	Natco Pharma	Generic everolimus alternative with similar therapeutic spectrum
Votubia 5 mg	Novartis	Approved for TSC-associated SEGA in adult and pediatric patients

📚 References

Drugs.com – Dosage guidelines for cancer & transplant (drugs.com)
Mayo Clinic – Overview of everolimus clinical use (mayoclinic.org)

🩺 Specialist Perspective – Dr. Arjun Mehta, MD

“Generics like Torinat make high-cost mTOR therapies more accessible while maintaining efficacy and safety standards. With close monitoring, it’s a powerful option in oncology and transplant medicine.”

⚠️ Disclaimer

This content is for informational purposes only. Torinat 10 mg (Evermil) should be used under physician supervision. Always consult a specialist prior to use.