Name: Triomune 30
SKU: 26026
Availability: InStock

🏷️ Parameter	🔍 Details
🧬 Active Ingredients	Stavudine 30mg + Lamivudine 150mg + Nevirapine 200mg
💊 Indication	HIV-1 Infection (First-line ART regimen)
🇺🇸 US Brand	No direct equivalent; components available separately
🏭 Manufacturer	Cipla Ltd.
📦 Packaging	Bottle 30 pills
💪 Strength	30mg/150mg/200mg per tablet
🚚 Delivery Time	7–14 days (Worldwide)

🧬 Introduction to Triomune

Triomune by Cipla is a fixed-dose combination of three antiretrovirals:

⚡ Stavudine 30mg (NRTI: inhibits viral DNA synthesis)
🔒 Lamivudine 150mg (NRTI: chain terminator)
🔥 Nevirapine 200mg (NNRTI: blocks reverse transcriptase)

Approved as first-line therapy for HIV-1 in resource-limited settings, it offers:

✅ Simplified dosing (1 tablet BID after 14-day Nevirapine lead-in)
✅ Cost-effective viral suppression
❗ Black-box warnings for mitochondrial toxicity (Stavudine) and hepatotoxicity (Nevirapine)

Cipla’s formulation revolutionized global HIV access but is now phased out in developed countries due to toxicity concerns.

💊 Dosage & Indications

💉 Indication	🧪 Dosage	⏱️ Frequency	💡 Notes
Adults >60kg	1 tablet BID	Twice daily	After 14-day Nevirapine lead-in (200mg/day)
Adults <60kg	Not recommended	–	Use separate formulations
Children	Contraindicated	–	Use weight-adjusted doses
Renal Impairment	Avoid if CrCl <50 mL/min	Contraindicated	Lamivudine accumulation

⚠️ Side Effects, Storage & Warnings

❗ Common Side Effects:
- Peripheral neuropathy (Stavudine)
- Rash (Nevirapine)
- Nausea (Lamivudine)
🚫 Serious Effects:
- Lactic acidosis (Stavudine)
- Fatal hepatotoxicity (Nevirapine)
- Pancreatitis (Stavudine)
❄️ Storage: 15–30°C; protect from moisture (keep in blister until use).
⚠️ Warnings:
- Contraindicated in moderate-severe liver disease
- Avoid in women with CD4>250/mm³ or men with CD4>400/mm³
- Monitor for lipoatrophy (face/limb fat loss)

🌍 Global Availability & Shipping

🌎 Region	📦 Shipping	💵 Price (60 tablets)	📜 Prescription
🇺🇸 USA	✅ Restricted	$55–$90	Required
🇬🇧 UK	✅ Yes	£45–£75	Required
🇦🇺 Australia	❌ No	–	Not available

🔗 Related Indian Alternatives (Different in Same Category)

💊 Product Name	🏭 Manufacturer	🔗 Internal Link
Viraday (Efavirenz/Emtricitabine/Tenofovir)	Cipla	viraday
Doluteg-L (Dolutegravir/Lamivudine)	Emcure	doluteg-l
Tenvir-EM (Tenofovir/Emtricitabine)	Cipla	tenvir-em
Abamune-L (Abacavir/Lamivudine)	Cipla	abamune-l
Lopimune (Lopinavir/Ritonavir)	Cipla	lopimune
Covihope-D (Dolutegravir/Ritonavir)	Hetero	covihope-d

📚 External Medical References

🩺 Expert Commentary

Dr. Rajiv Malhotra, HIV Researcher:
*”While Triomune expanded ART access globally, its Stavudine component causes irreversible lipoatrophy in 20% of patients. Modern regimens like [viraday] (Tenofovir-based) are safer first-line options. Reserve Triomune for salvage therapy when alternatives are unavailable.”*

📌 Disclaimer

This information is not medical advice. Use under physician supervision. Cipla’s Triomune carries FDA black-box warnings for hepatotoxicity and mitochondrial toxicity.

💡 Clinical Protocol:

Stavudine Toxicity Monitoring:
- Baseline & quarterly: Lactate levels, liver function
- Monthly: Peripheral sensation tests
Nevirapine Lead-in:
- 200mg/day × 14 days → if no rash, start Triomune BID
Cipla Tablet ID: “CIPLA” logo + “T30” on tablets
Discontinuation Criteria:
- Lactate >5 mmol/L + symptoms
- ALT >10× ULN
- Severe lipoatrophy
Alternative Regimen: Switch to [tenvir-em] if weight loss >10% in limbs