Viraday

🧬 Introduction to Viraday

Viraday by Cipla is a complete once-daily HIV regimen combining:

• 🦴 Tenofovir DF 300mg (NRTI: nucleotide reverse transcriptase inhibitor)

• 🧬 Emtricitabine 200mg (NRTI: cytidine analog with dual HIV/HBV activity)

• 🧠 Efavirenz 600mg (NNRTI: CNS-penetrating reverse transcriptase inhibitor)

Approved for HIV-1 treatment in patients ≥40kg, this 30-tablet bottle offers:

• ✅ Simplified dosing (1 tablet at bedtime)

• ✅ High barrier to resistance

• ✅ WHO-preferred first-line regimen

• ⚠️ Neuropsychiatric side effects (50% incidence)

• ❗ Black-box warning for severe depression/suicidality

Cipla’s generic version provides affordable access to this gold-standard regimen.

💊 Dosage & Indications

⚠️ Side Effects, Storage & Warnings

• ❗ Common Side Effects:

  • Dizziness (52%)

  • Vivid dreams (48%)

  • Rash (30%)

• 🚫 Serious Effects:

  • Severe depression/suicidal ideation

  • Fanconi syndrome (Tenofovir-induced kidney damage)

  • Stevens-Johnson syndrome

• ❄️ Storage: 15–30°C; keep bottle tightly closed (desiccant included).

• ⚠️ Critical Warnings:

  • Contraindicated in psychiatric disorders or seizure history

  • Baseline & annual: Bone mineral density scans

  • Monthly renal monitoring (CrCl, urine glucose/protein)

🌍 Global Availability & Shipping

🔗 Related Indian Alternatives (Different in Same Category)

📚 External Medical References

1. WHO: Consolidated HIV Guidelines 2023

2. FDA: Atripla Black Box Warning

3. DHHS: Efavirenz Neuropsychiatric Management

🩺 Expert Commentary

Dr. Karan Sharma, HIV Specialist:
“Viraday’s once-daily convenience comes with significant CNS effects. I initiate it on Fridays so patients can adjust over weekends. For those with depression history, [dolutranz] (Dolutegravir-based) is safer. Cipla’s bottle has light-blocking properties to protect Efavirenz from photodegradation.”

📌 Disclaimer

This information is not medical advice. Use under physician supervision. Cipla’s Viraday carries black-box warnings for severe psychiatric adverse reactions.

💡 Clinical Protocol:

• Neuropsychiatric Management:

  Symptom	Action
  Mild dizziness	Take 2 hours before bedtime
  Vivid dreams	Reassurance + temporary sleep aid
  Suicidal thoughts	IMMEDIATE DISCONTINUATION

• Renal/Bone Monitoring Schedule:

  Test	Frequency	Action Threshold
  Creatinine Clearance	Quarterly	<50 mL/min
  Urine Protein	Semi-annual	>500 mg/24h
  DEXA Scan	Baseline, Biannual	T-score <-2.0

• Bottle Specifications:

  • Amber HDPE bottle with UV protection

  • “CIP-VD” embossed on tablets

  • Silica gel canister (do not eat)

• Drug Interactions:

  • ⚠️ Rifampicin: Reduces Efavirenz levels (avoid)

  • ⚠️ PPIs: Reduce Atazanavir concentrations

  • ⚠️ Warfarin: Requires INR monitoring