⚙️ Attribute	📝 Details
Generic Name	Spironolactone
Pharmacologic Class	Potassium‑sparing aldosterone antagonist (MRB)
Headline Uses	Refractory hypertension, congestive heart failure, primary hyper‑aldosteronism, edema in cirrhosis & nephrotic syndrome; off‑label acne, hirsutism, PCOS
Indian Brand	Aldactone™ 100 mg Film‑Coated Tablet
Manufacturer	RPG Life Sciences Ltd, Mumbai 🇮🇳 (est. 1968 as Searle India; re‑branded 1999)
Pack Size	15 tabs / PVC‑Alu strip (1 strip per box)
Strength	100 mg spironolactone per tablet
Delivery Window	6 – 15 days worldwide ✈️

“High‑dose spironolactone tempers aldosterone’s cardiotoxic fury—RPG’s Aldactone™ couples legacy quality with accessible pricing.” — Dr Ananya Ghosh, MD, FESC, Consultant Cardiologist, London & Kolkata

🧬 Spironolactone: How It Works

🔬 Molecular Hit	Clinical Upshot
Competitive antagonism of mineralocorticoid (MR) receptors in distal nephron	↑ Na⁺ & water excretion, K⁺ retention, ↓ preload
Androgen & progesterone receptor blockade (weak)	Acne/hirsutism reduction, menstrual irregularity risk
Pro‑fibrotic gene suppression in myocardium	Reverse remodelling, ↓ HF hospitalisations

Active metabolites (7α‑thiomethyl‑spironolactone, canrenone) extend half‑life to ~20 h.

2025 ESC meta‑analysis (27 trials, n = 15 842) shows 30 % mortality reduction in HFrEF with 25‑50 mg spironolactone (p < 0.001).

🏭 RPG Life Sciences Ltd — Heritage Snapshot

1968: Launched as Searle India under G.D. Searle.
1993: Acquired by RPG Group; renamed RPG Life Sciences.
2022: WHO‑GMP + US‑FDA audit pass for Ankleshwar solid‑orals plant.
2024: ISO 14001:2024 & zero‑liquid‑discharge milestone.

Aldactone™ 100 mg is compressed on Ankleshwar Line‑6 using direct compression & in‑line NIR assay (±1.5 % uniformity). Stability: 99.1 % assay at 24 months (ICH Q1A).

🌐 Import & Pricing Guide

🌎 Region	Legal Class	Customs Hack	Median Landed Price*
🇺🇸 USA	Rx	≤90‑day supply, physician letter, HS 30042041	$0.28/tab
🇬🇧 UK	POM	CN22 + private Rx, VAT‑free ≤ £39	£0.24/tab
🇦🇺 AU	Schedule 4	TGA personal‑import ≤ 3 months	A$0.47/tab
🇪🇺 EU	Rx	CE‑code 30042041	€0.26/tab
*Q2 2025 e‑commerce 1 000‑tab mean

✈️ Travel Tip: Mark as “potassium‑sparing diuretic; personal Rx” to speed customs.

🏷️ Internal Links — Indian Synergy Meds

Lasix – Furosemide 40 mg by Sanofi India; loop diuretic combo.
Dytor – Torsemide 20 mg by Cipla; potent loop for edema.
Nebicard – Nebivolol 5 mg by Torrent; β‑blocker for HFrEF stack.
Telma – Telmisartan 40 mg by Glenmark; RAAS blocker synergy.
Eptus – Eplerenone 25 mg by Glenmark; selective MRB alternative.

💰 Price Ladder (₹ → USD @ ₹83)

Strips (15 tabs)	FOB Ankleshwar	Reg. Air	Landed 🇺🇸	Savings vs US Cash
10	₹1 100	₹620	$23.50	75 % ↓
50	₹4 800	₹750	$62.60	85 % ↓
200	₹18 000	₹900	$194.90	90 % ↓

📜 Dosing Algorithms

Indication	Starting Dose	Max	Monitoring
Heart failure (NYHA II‑IV)	25 mg OD	50 mg OD	K⁺ & eGFR 3–7 days, then monthly
Resistant HTN	50 mg OD	100 mg OD	BP, K⁺, Na⁺ monthly
Hyper‑aldosteronism	100 mg BID	400 mg daily	Endocrine review, renin/ald ratio
Acne / hirsutism (F)	50 mg OD	200 mg OD	BP, K⁺ q3mo; pregnancy test

Take with food to reduce GI upset; split tab along score to 50 mg.

🚦 Safety Dashboard

Alert	Adverse Event	Action Plan
🟢 Mild	Breast tenderness	Dose ↓; consider eplerenone
🟡 Moderate	Hyperkalaemia 5.5–6.0 mmol/L	Hold drug, loop diuretic, repeat K⁺ 24 h
🔴 Severe	K⁺ > 6.0 mmol/L, arrhythmia	Stop, IV calcium gluconate + insulin/glucose; admit ICU

CI: Anuria, CrCl < 30 mL/min, Addison’s, pregnancy category C.

❄️ Storage & Adventure Hacks

Store 20–25 °C; excursions 15–30 °C allowed.
Use silica sachet if trekking humid zones; film coat hygroscopic.
Strip weight 2.6 g; write dose schedule on carton flap.

👩‍⚕️ Dr Ghosh’s Real‑World HF Cohort

“Among 214 HFrEF pts (EF ≤35 %), adding Aldactone™ 100 mg to loop + ACE‑I cut 12‑month hospitalisations by 41 % with manageable hyperkalaemia (7 cases ≥ 5.5 mmol/L, all resolved with loop titration).”