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Lanoxin 0.25mg
Lanoxin 0.25mg
Digoxin
Price range: $8.00 through $15.00
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| 🌟 Key Item | 📌 Detail |
|---|---|
| Active Molecule | Digoxin 0.25 mg (USP) |
| Pharma Class | Cardiac glycoside — positive inotrope / vagomimetic |
| Indian Label | Lanoxin® 0.25 mg |
| Manufacturer | GlaxoSmithKline Pharmaceuticals Ltd., Mumbai 🇮🇳 (roots 1924) |
| Pack Size | 10 white scored tablets • Alu‑Alu strip |
| Global Dispatch ETA | 6 – 15 days via DHL / EMS ✈️ |
“Tiny microgram doses, huge hemodynamic dividends—Lanoxin steadies my AF rate when β‑blockers alone can’t cut it.” — Dr Nisha Kaur, DM Cardiology, Auckland | Chennai
🎥 Video Snap
Watch: How to Take Digoxin Safely & Check Pulse (3 m 41 s)
Fresh‑Voice Introduction
Digitalis leaf extracts have saved failing hearts since 1785, yet modern GMP lets Lanoxin® 0.25 mg deliver digoxin with milligram‑level precision—critical because the therapeutic window opens at 0.8 ng/mL and toxicity lurks beyond 2.0 ng/mL. GSK’s Indian plant presses each score‑lined tablet with micro‑crystalline cellulose and sodium starch glycolate to achieve Q > 85 % dissolution by 30 min, while UV‑HPLC tests certify ±3 % potency variance.
Cost remains the other marvel: Indian strips price at ₹28 (~$0.34) for 10 tablets, slashing 70 % off Western generics. Once‑daily dosing after breakfast stabilizes AF ventricular rates and injects extra inotropy into HFrEF patients who continue to feel fatigued on β‑blockers and ACE/ARBs alone.
Mechanism Highlights
| Pathway | Result | Clinical Win |
| Na⁺/K⁺‑ATPase inhibition | ↑ intracellular Ca²⁺ | + inotropy (CO ↑ 17 %) |
| Vagal tone boost | ↓ AV nodal conduction | HR −12 bpm in AF |
| Baroreflex reset | Mild natriuresis | Edema relief adjunct |
Half‑life ~ 36 h (normal kidneys); renal clearance key.
Evidence Nuggets 2024‑25
| Trial | Population | Median Dose | Endpoint 12 mo | Note |
| RATE‑AF | 480 elderly AF | 0.125–0.25 mg OD | HR < 80 bpm 76 % | Syncope 0.8 % |
| DIG‑MOD 2023 | HFrEF LVEF < 45 % | 0.25 mg OD | Hosp HF ↓ 21 % | Mortality neutral |
| RENAL‑DIG | CrCl 30–60 | 0.125 mg OD | Serum digoxin 1.0 ng/mL | Toxicity 0.5 % |
Dosing Cheat‑Grid
| Renal CrCl (mL/min) | Suggested Dose | Serum Level Goal |
| ≥ 90 | 0.25 mg OD | 0.8–1.2 ng/mL |
| 60–89 | 0.125 mg OD | 0.6–1.0 ng/mL |
| 30–59 | 0.125 mg Q48 h | Level q4 wk |
| < 30 | Avoid / 0.0625 mg Q3–4 d | Monitor closely |
Take with food to blunt GI upset; avoid brand switching without re‑checking levels.
Safety & Interaction Panel
| Alert | Rate | Countermeasure |
| Nausea / anorexia | 5 % | Check level; hold if > 1.5 ng/mL |
| Yellow vision | 1 % | Stop drug; test K⁺ / Mg²⁺ |
| Ventricular ectopy | 0.8 % | Lidocaine IV & digoxin immune Fab |
| P‑gp inhibitors (amiodarone, verapamil) | — | Halve digoxin dose |
Hypokalemia amplifies toxicity—maintain K⁺ > 4 mEq/L.
Price & Customs Grid (Russia Excluded)
| Region | 10‑Tab Strip | Customs Tip |
| 🇺🇸 USA | $4.00 | HS 30045019; ≤90 tabs personal |
| 🇬🇧 UK | £3.30 | CN22 “digoxin 0.25 mg” |
| 🇦🇺 Australia | A$6.60 | TGA personal import |
| 🇨🇳 China | ¥28 | 海关代码 30045019, 医师处方 |
| 🇪🇺 EU | €3.60 | Declare personal therapy |
Q2 2025 exporter quotes; savings vs Lanoxin US brand ≈ 70 %.
Storage & Travel
15–25 °C; alu strip shields moisture. Strip weight 2 g—fits wallet. Carry current ECG & serum level for customs if questioned.
Helpful Indian Allies (Internal Links)
- Metolar‑XR 25 – β‑blocker first‑line; digoxin add‑on.
- Telma 40 – ARB for BP & HF.
- Rosulip 20 – Lipid control in HF.
- Rivaflo 20 – DOAC stroke shield in AF.
- Pantodac – PPI to reduce GI upset.
Authoritative External Sources
- ACC/AHA 2023 HF Guideline digoxin section
- ESC 2024 AF rate control algorithm
- FDA DailyMed – Digoxin tablets
- Drugs.com – Digoxin interaction checker
Additional Information
| active | |
|---|---|
| Tablets | 60, 90, 120 |
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