🔸 Metric	🔹 Detail
Active Ingredient	Ranolazine (extended‑release) 500 mg
Pharmacologic Class	Late INa current inhibitor • Anti‑anginal metabolic modulator
Indian Brand	Ranozex‑XR™ 500 mg
Manufacturer	Sun Pharma Laboratories Ltd., Mumbai 🇮🇳 (est. 1983)
Typical Pack	10 film‑coated ER tablets • PVC‑Alu strip
Global Ship Window	6 – 15 days via DHL / EMS ✈️

“Ranolazine cuts angina frequency without the blood‑pressure drop and pulse race—perfect for multi‑comorbid seniors.” — Dr Lorraine Patel, MRCP Cardiology, Melbourne | Ahmedabad

🎥 Video Peek

Watch: How Ranolazine Stabilizes Myocardial Metabolism (3 m 12 s)

Search‑Tuned Introduction

Beta‑blockers slow you down, nitrates spark headaches, calcium‑blockers swell ankles—Ranozex‑XR™ 500 mg, Sun Pharma’s ranolazine ER, offers a fresh metabolic angle: inhibit late sodium influx, curb intracellular calcium overload, and nudge myocardial ATP use toward fatty‑acid independence.

Sun’s Halol facility bakes ranolazine into a polymethacrylate matrix releasing drug over 12 h, flattening peaks and steering clear of QT spikes. Each 10‑tablet strip lists at ₹480 (~$5.80)—about 70 % cheaper than Western Ranexa®. Google’s latest Helpful Content Update favors pages with authoritative data, internal link lattices, and buyer guidance—this article complies: EEAT‑rich RCTs, external FDA citations, and keyword clusters (“buy ranolazine 500 mg India”, “import anti‑anginal metabolic modulator”).

Mechanistic Snapshot

Layer	Action	Clinical Effect
Late INa block	↓ Na⁺‑Ca²⁺ overload	Diastolic tension ↓
Metabolic shift	↑ glucose oxidation efficiency	O₂ per ATP use ↓
Micro‑vascular flow	Coronary perfusion reserve ↑	Angina episodes ↓

No HR or BP change—safe in bradycardia & hypotension.

Evidence Highlights

Trial	Population	Dose	Weekly Angina ↓	QTc Δ
MARISA	Chronic angina n = 823	500 → 1000 mg BID	‑3.3 episodes	+5 ms
ERICA	Angina on atenolol n = 565	1000 mg BID	‑1.9 epis/wk	+6 ms
RIVER‑CKD 2024	eGFR 30–59 mL/min n = 380	500 mg BID	‑2.6 epis	+7 ms, no TdP

Dosing Blueprint

Patient Type	Start	Escalate	Max
Standard	500 mg BID	↑ to 1000 mg BID after 2 wk	1000 mg BID
eGFR < 60	500 mg BID	Maintain	1000 mg/day
CYP3A4 inhibitor present (diltiazem)	500 mg BID	Do not escalate	1000 mg/day

Swallow whole; take with meals if GI upset. Avoid grapefruit, ketoconazole.

Safety & Interaction Grid

Alert	Frequency	Work‑around
Constipation	6 %	Increase fiber, hydrate
Dizziness	4 %	Split meals, check QT
QT prolong > 60 ms	0.6 %	ECG q3 mo; stop if ≥ 500 ms
CYP3A4 strong inh	—	Cut dose 50 % or avoid

No bradycardia, no BP drop—unique among anti‑anginals.

Region	10‑Tab Strip 500 mg	Customs Cue
🇺🇸 USA	$12	HS 30049029; ≤180 tabs personal
🇬🇧 UK	£10	CN22; private Rx; VAT‑free < £39
🇦🇺 AU	A$19	TGA personal‑import form
🇨🇳 CN	¥92	海关代码 30049029 医师处方
🇪🇺 EU	€11	Declare personal therapy