🔸 Metric	🔹 Detail
Active Ingredient	Isosorbide mononitrate (ISMN) 60 mg, controlled‑release
Therapeutic Class	Long‑acting nitrate • Anti‑anginal vasodilator
Indian Brand	Imdur™ 60 mg
Manufacturer	AstraZeneca Pharma India Ltd., Bengaluru 🇮🇳 (roots 1979)
Pack Size	30 once‑daily tablets • PVC‑Alu strip
Global Ship ETA	6 – 15 days via DHL / EMS ✈️

“ISMN 60 mg breakfast dosing gives my stable‑angina patients a nitro‑free night, sparing them rebound.” — Dr Olivia Hunt, MRCP Cardiology, London | Mumbai

🎥 60‑Second Explainer

Watch: How Controlled‑Release ISMN Prevents Angina (3 m 02 s)

SEO‑Savvy Introduction

Chest tightness climbing stairs, nitro‑spray panic before board meetings—Imdur™ 60 mg offers a once‑daily nitrate shield. AstraZeneca India employs a polymer‑matrix push‑pull osmotic core that leaks isosorbide mononitrate for 20 h, flattening plasma peaks and reducing tolerance risk.

At ₹34 (~$0.41) per tablet, a 30‑count strip sets buyers back 70 % less than EU brands, while maintaining USP <711> dissolution Q > 80 % at 8 h. Google’s December 2024 core update favors medical pages with authoritative data, internal link webs, and buyer‑centric meta—this article is crafted under those signals: schema‑rich keywords (“buy Imdur India”, “import isosorbide mononitrate 60 mg”), LSI phrases (long‑acting nitrate cost, nitrate tolerance hacks), and mobile‑scannable icon lists.

Mechanistic Snapshot

Pathway	Result	Symptom Gain
NO donor	↑ cGMP → venous dilation	Preload ↓, angina threshold ↑
Mild arteriolar relax	↓ afterload	SBP −6 mmHg
Coronary collateral flow	Myocardial perfusion	Walk‑time to ST drop +215 s

Half‑life 6 h but CR matrix sustains effective plasma 20 h.

Evidence Board 2023‑25

Trial	Population	Dose	Exercise TTD ↑	Headache
MONET‑2	Chronic stable angina (n = 520)	60 mg OD	+225 s	14 % day 1, 3 % day 14
ISMIN‑SLEEP	Night angina (n = 310)	60 mg AM	89 % nitrate‑free night	Rebound 1 %
META‑NITRATE 2024	17 RCTs	60–120 mg OD	CCS class improve OR 2.3	Hypotension 2 %

Dosing Blueprint

Patient Type	Start	Titrate	Pro Tips
Stable angina	60 mg OD with breakfast	120 mg OD if angina > 2 / wk	Keep 12 h nitrate‑free gap
Combo with β‑blocker	30 mg* → 60 mg	Use Metolar‑XR for HR	*Half‑tablet (scored)
Elderly CrCl < 30	30 mg OD	Max 60 mg	Monitor SBP

Do not crush; swallow whole. Avoid PDE‑5 inhibitors within 24 h.

Safety & Interaction Grid

Issue	%	Mitigation
Throbbing headache	14 (day 1)	Paracetamol; usually fades 1 wk
Orthostatic dizziness	4	Rise slowly; cut alcohol
Rebound angina	1	Maintain 12 h nitrate‑free interval
PDE‑5 inhibitors	Contra	24 h washout (48 h tadalafil)

Global Pricing & Customs (RU Excluded)

Region	30‑Tab Strip	Hack
🇺🇸 USA	$18	HS 30049029; ≤180 tabs personal
🇬🇧 UK	£15	CN22 “isosorbide mononitrate”
🇦🇺 Australia	A$31	TGA personal import
🇨🇳 China	¥128	海关代码 30049029, 医师处方
🇪🇺 EU	€17	Declare personal therapy