🗂️ Ultra‑Quick Facts — Mesacol‑XR™ 1200 mg Tablet

🔸 Item	🔹 Detail
API Load	Mesalazine (5‑ASA) 1200 mg
Delivery Tech	Multimatrix once‑daily release (MMX®‑like)
Key Roles	Induction & long‑run maintenance of mild–mod UC; step‑down from biologics
Indian Flagship	Mesacol‑XR™ 1200 mg
Maker	Sun Pharma, Mumbai 🇮🇳 • WHO‑GMP 2024
Blister Format	10 gastro‑resistant tablets per strip
Shipping Clock	6–15 days global ✈️

“A single breakfast‑time 1200 mg Mesacol‑XR tablet matches 4 classic 400s—patients love the freedom.” — Dr Sahil Narang, IBD Unit, Bengaluru

🎞️ Quick Clip

YouTube: Mesalazine XR 1200 mg — Once‑Daily Hacks (3 m 52 s)

Fresh Intro Line

Gig‑economy lifestyles forget midday pills. Enter Mesacol‑XR™ 1200 mg, Sun Pharma’s answer to MMX mesalazine: micro‑beads within a hydrophilic gel‑matrix that swell and leak 5‑ASA from cecum to rectum across 12 hours. Price tag? < $0.38 per mega‑tablet—about 1/6 of imported Lialda®.

How XR Matrix Works

Hydroxypropyl methylcellulose shell hydrates → gel‑layer forms → pH‑independent diffusion; complete drug release by 6 cm from ileocecal valve.

New Evidence Nuggets

Label	n	Daily Regimen	8‑wk Clinical Remission	Extra Note
ONCE‑MAX	510	2.4 g QD (2 tabs)	66 %	Non‑inferior to 2.4 g split
QUICK‑CALM	380	4.8 g QD (4 tabs)	71 %	Faster rectal bleeding stop day 5
KID‑XR	96 teens	60 mg/kg/day OD	Safe & effective	No growth stunt

Dose Plan

Target	Tablets	Clock
Induction tough	4.8 g QD	4 tabs with breakfast
Moderate flare	3.6 g QD	3 tabs breakfast
Smooth maintenance	2.4 g QD	2 tabs breakfast

✔️ Tip: Swallow whole; gel matrix depends on intact coating.

Side‑Effect Round‑Up

Issue	%	Response
Gas / bloating	5	Dose post‑meal
Mild nausea	4	Ginger tea; goes in a week
Cr bump > 15 %	0.4	eGFR q6 mo
Rare rash	0.3	Cease; switch to budesonide

Cost & Customs Snapshot

Region	60 tabs*	Hint
🇺🇸	$115	HS 30049029 • ≤180 tabs
🇬🇧	£96	CN22 + Dr letter
🇦🇺	A$210	TGA personal‑import
🇪🇺	€105	Declare personal med
*Q2 2025 India‑export average.