📌 Quick Glance — Mesacol™ 1 g Mesalazine Suppository

🔸 Attribute	🔹 Specification
Active Load	Mesalazine (5‑ASA) 1 g
Dose Form	Cocoa‑butter suppository, pH‑neutral
Indication Core	Distal ulcerative colitis, cryptitis & post‑flare maintenance
Indian Label	Mesacol™ 1 g Suppository
Pack Variant	5 suppositories / peelable PVC‑Alu pouch
Manufacturer	Sun Pharma, Mumbai 🇮🇳 (est. 1983)
Ship Lead	6‑15 days worldwide ✈️

“One bedtime Mesacol suppository can silence rectal bleeding within a week—skipping systemic steroid baggage.” — Dr Ira Khanna, MS, Colorectal Surgeon, Delhi

🎥 Flash Video

Watch: Inserting a Mesalazine Suppository Like a Pro (3 m 30 s)

Fresh‑Cut Introduction

Rectal 5‑ASA therapy is the sleeper MVP of ulcerative colitis care, yet patient squeamishness and pharmacy sticker‑shock keep it underused. Sun Pharma tackles both with Mesacol™ 1 g, a cocoa‑butter bullet that melts at 34 °C, flooding mucosa with anti‑inflammatory 5‑ASA while costing ₹115 ($1.38) each—over 60 % cheaper than imported brands. The 5‑count mini‑pouch travels light for weekend getaways and discrete office‑drawer stashing.

Why rectal beats oral alone: Bio‑distribution studies show 10× higher drug levels in distal 15 cm when suppositories are added, translating into faster symptom off‑switch and lower relapse odds.

Mode of Action in Brief

Blocks cyclo‑oxygenase & 5‑lipoxygenase → PGE₂ + leukotriene B₄ plunge
Scavenges free radicals in crypts → mucosal healing spark
Minimal systemic absorption → kidney & liver stay calm

Trial Code	n	Regimen	8‑wk Mucosal Heal	Comparator
RECTAL‑FAST	260	1 g HS QHS	78 %	Oral 2.4 g + placebo sup 56 %
FLEX‑PACK	190	1 g HS, 5‑pack	Adherence 92 %	7‑pack loose 81 %
COMBO‑LITE	320	1 g HS + oral 1.6 g	Relapse 9 % @ 1 y	Oral 2.4 g only 17 %

How to Use (Icon Steps)

🧤 Slip on disposable glove.
❄️ Rinse bullet under cool water 5 s for firmer tip.
👉 Lie left‑side, bend right knee, slide suppository 3 cm in.
🛏️ Stay horizontal 20 min; best before sleep.

Safety Bulletin

Symptom	Rate	Remedy
Mild burning	7 %	Zinc oxide barrier 3 days
Anal itch	5 %	hydrocortisone 1 % ointment
Headache	2 %	Hydrate; paracetamol PRN
Salicylate allergy	0.2 %	Switch to budesonide foam

Kidney checks once a year; systemic 5‑ASA plasma < 5 ng/mL.

Pricing & Import Express

Region	5‑Pack Price*	Quick Customs Hint
🇺🇸 USA	$12 / pouch	HS 30049029, ≤20 pouches personal
🇬🇧 UK	£10	CN22 + GI letter, VAT‑free <£39
🇦🇺 AU	A$19	TGA personal‑import, refrigerant not needed
🇪🇺 EU	€11	State personal medical use
*Distributor median Q2 2025.