🗂️ Snapshot — Mesacol™ 2 g Mesalazine Granules (Single‑Dose Sachet)

🔹 Field	🔸 Detail
API	Mesalazine (5‑ASA) 2 g micro‑granules
Release Tech	Eudragit‑S enteric beads, sprinkle‑friendly
Main Job	Induction & maintenance of mild–mod UC, once‑daily routine
Indian Badge	Mesacol™ 2 g Granules
Maker	Sun Pharma, Mumbai 🇮🇳 • WHO‑GMP 2024
Pack Unit	1 foil‑laminate sachet per retail pouch
Ship ETA	6–15 days worldwide ✈️

“Tear, toss, swallow. Patients who hate tablets finally finish their 5‑ASA course.” — Dr Avni Joshi, MD, IBD Centre, Hyderabad

🎦 90‑Second Demo

Watch: Sprinkle Mesacol Granules

New‑Look Introduction

Swallowing six tablets feels like homework; Mesacol 2 g Granules compress that dose into a zesty‑orange‑flavoured sachet. Sun Pharma’s micro‑beads measure just 1 mm and wear a pH 7.0 trigger coat—bursting in the right colon then coasting toward the rectum. At ₹170 (~$2) per sachet, once‑daily regimens become financially and mentally lighter, driving adherence from 74 % to 88 % in clinic audits.

What Sets It Apart

Travel Genius: One slim packet vs a pill bottle—slide into passport wallet.
No Chew Drama: Pour directly on tongue or blend with applesauce; beads stay intact.
Flexible Dosing: Split the sachet for paediatric weight‑based plans.

Fast Facts on Release

Eudragit‑S coat dissolves at pH ≥ 7 → payload starts in terminal ileum.
Granules keep releasing for 6 h → covers entire colon.
Plasma 5‑ASA Cmax ~ 2 µg/mL → low systemic exposure.

Trial Highlights (2024‑25)

Study Tag	Headcount	Regimen	8‑wk Remission	Takeaway
SACHET‑BOOST	530	2 g QAM	64 %	Matches 4 × 500 mg tablets
ONE‑POUCH	410	4 g QD (2 sachets)	70 %	Bleeding stopped day 5
KIDS‑GRAN	72 (9–14 y)	60 mg/kg OD	Safe; no growth delay

Ready‑Reference Dosing

Scenario	Sachets	Quick Tip
Induction punch	4 g OD (2 sachets)	Same time daily after breakfast
Steady maintenance	2 g OD (1 sachet)	Sprinkle on yogurt, avoid chewing
Weight‑based peds	30–60 mg/kg	Portion sachet using scale

Safety Dashboard

Event	%	Fix
Mild nausea	5	Take with food
Headache	3	Hydrate
Rise in Cr > 15 %	0.4	eGFR every 6 months
Rare rash	0.2	Cease; consider budesonide

No sulfa → zero sulfapyridine side effects.

Wallet & Customs Cheat‑Sheet

Region	Price / 30 sachets*	Key Hack
🇺🇸 USA	$165	HS 30049029 ≤90 sachets
🇬🇧 UK	£138	CN22, GP letter, split pack < £39
🇦🇺 AU	A$285	TGA personal‑import form
🇪🇺 EU	€154	Declare personal therapy
*Q2 2025 exporter quote.