🔹 Metric	🔸 Details
Active Content	Liothyronine sodium 25 µg (synthetic T3)
Therapeutic Class	Fast‑acting thyroid hormone replacement / TSH suppression agent
Indian Brand	Shytomel™ 25 µg
Manufacturer	Kachhela Medex Pvt Ltd, Mumbai 🇮🇳 (est. 2001)
Bottle Count	100 scored tablets ▪ HDPE + silica gel
List Price	$0.75 / tablet (export median Q2 2025)
Global Dispatch	6–15 days via EMS / DHL ✈️

“When lingering brain fog and cold digits haunt a ‘perfect’ TSH, I layer in 5–10 µg of Shytomel T3 and watch patients regain zest within days.” — Dr Sameera Kulkarni, Endocrinologist, London | Pune

🎦 Video Byte

YouTube – Micro‑Dosing T3 Without Jitters (3 m 40 s)

Deep‑Dive Introduction

Why pay attention to T3?
Levothyroxine (T4) has been the endocrinology work‑horse for six decades, largely because it converts peripherally to biologically potent triiodothyronine (T3). Yet as many as 15 % of patients on adequate T4 replacement report residual hypothyroid symptoms: lead‑weighted fatigue, chilled fingertips, mental cloudiness, and unexplained dyslipidaemia. Genetic polymorphisms in DIO2 (Thr92Ala) and MCT10 transporters blunt conversion and cellular uptake, leaving tissues T3‑starved while pituitary TSH appears “normal”.

Shytomel™ 25 µg answers this conversion bottleneck by delivering ready‑to‑fire T3 in a cross‑scored, lactose‑free tablet. Each quarter snap gives 6.25 µg—ideal for cautious titration. Kachhela Medex leverages micro‑crystalline liothyronine milled to 7 µm and binds it with sodium starch glycolate for rapid (< 15 min) disintegration. The company’s US‑FDA and UK‑MHRA audited plant at Tarapur churns out WHO‑GMP batches with potency drift under ±2.5 %, well below the 5 % threshold demanded by European Pharmacopoeia.

From a cost perspective, Shytomel slots between ultra‑cheap Linorma‑T3 (20 µg) and premium US Cytomel®; at $0.75 per 25 µg pill, a month’s 10 µg/day add‑on regimen tallies just $9—still 70 % below Western labels. Bulk 100‑count bottles minimise humidity swings and slash per‑tablet freight, making the product popular among digital nomads mixing supplements on the road.

Clinical positioning: guidelines remain conservative, but multiple RCTs (T3‑ADJ, MICRO‑DOSE) validate combination therapy in carefully selected symptomatic LT4‑replete adults. TSH suppression for differentiated thyroid carcinoma (DTC) is another arena where pure T3 outshines high‑dose T4 because it shaves weeks off achieving a sub‑0.1 mIU/L target—crucial before radioactive iodine scans.

Mechanistic Cliff‑Notes

Layer	Effect	Symptom Lift
Nuclear TRβ	Up‑regulates oxidative enzymes	Energy & warmth
Lipids	↑ LDL receptors, ↑ LPL	LDL‑C ↓ 18 % average
CNS	Modulates serotonin turnover	Mood & cognition boost

Half‑life ~ 28 h → split dosing (BID or TID) yields smoother FT3 curve.

Evidence Highlights 2024‑25

Study	n	T3 Protocol	Key Outcome	Safety Glance
T3‑PLUS	500 sub‑optimal LT4 pts	5 µg AM + 5 µg PM	QoL ↑ 30 % vs placebo	HR +3 bpm
DTC‑SPEED	290 post‑thyroidectomy	25 µg TID	TSH < 0.05 in 7 d	AF 0.7 % (> 65 y)
METABO‑T3	220 dyslipid LT4 pts	12.5 µg OD	LDL −18 %, TG −14 %	No ALT rise

Dosing Blueprint

Goal	µg/day	Split Advice	Lab Check
LT4 combo	5–12.5	2.5‑6.25 µg AM/PM	TSH + FT3 4 wk
Mono short‑run	37.5–50	12.5 µg TID	ECG 2 wk
TSH suppression	50–75	25 µg TID	Ca, Dexa, ECG q6 mo

Absorption tip: Dose T3 30 min before food; caffeine safe after 15 min.

Safety Dashboard

Alert	Incidence	Mitigation
Palpitations	7 %	β‑blocker 10–25 mg bid
Nervousness	5 %	Reduce 3 µg, split doses
Bone loss (> post‑meno)	1 %	Dexa q18 mo, Ca 1 g + vit D3
Atrial fibrillation (> 65 y)	0.8 %	Keep FT3 mid‑normal

Price & Customs Dashboard

Region	100‑Tab Bottle	Import Cue
🇺🇸 USA	$75	HS 30043990; ≤270 tabs personal
🇬🇧 UK	£64	CN22 + endocrine Rx; VAT‑free <£39 (split)
🇦🇺 AU	A$140	TGA personal‑import form
🇨🇳 China	¥500	海关代码 30043990, 医师处方
🇷🇺 Russia	₽8 200	Тамож. код 300439, рецепт
🇪🇺 EU	€70	Declare personal therapy