🔬 Active Ingredient (Generic Name):	Baclofen
💊 Indication:	Muscle Spasticity
🇺🇸 US Brand:	Lioresal
🏭 Manufacturer:	Novartis India Ltd. (Founded: 1994)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	25 mg
🚚 Delivery Time:	6–15 days

🌿 What is Baclofen 25 mg (Lioresal)?

Lioresal 25 mg contains Baclofen, a GABAB receptor agonist that reduces neuronal excitability in the spinal cord to relieve muscle spasticity. It’s indicated for spasticity due to multiple sclerosis, spinal cord injury, cerebral palsy, and other neurological disorders.

Extended-release or higher doses like 25 mg facilitate better control of severe spasticity. Clinical studies demonstrate that Baclofen 25 mg once in the morning and once at bedtime provides sustained relief over 24 hours, improving patient mobility and comfort.

Refer to the FDA label for Lioresal and the Drugs.com monograph for full prescribing and safety details.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C4H9Cl2NO
Molecular Weight	213.04 g/mol
Bioavailability	~70–80%
Metabolism	Minimal hepatic metabolism
Half-Life	3–4 hours

Baclofen’s binding to GABAB receptors inhibits excitatory neurotransmitter release, reducing muscle tone.

💡 Indications & Dosing

Condition	Dose
Muscle Spasticity	5–20 mg three to four times daily (max 80 mg/day)

Initiate at 5 mg three times daily. Titrate by 5 mg increments every 3 days based on response and tolerability.

⚠️ Warnings & Side Effects

Common:

Drowsiness, dizziness
Weakness, fatigue
Nausea

Serious (rare):

Seizures (abrupt withdrawal)
Hypotension
Hallucinations

Avoid abrupt discontinuation. Monitor renal function and mental status in long-term users.

🏥 Storage Instructions

Store at 20–25°C. Protect from moisture and light. Keep tablets in original blister; out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only; branded Lioresal and generic Baclofen.
UK & EU: Prescription required; widely available as Baclofen.
Australia: Prescription and TGA approval for import.

Import from India may save costs; ensure compliance and valid prescription.

🔗 Related Muscle Relaxants

Lioresal 10 mg – standard dose by Novartis.
Liofen 10 mg – Baclofen by Sun Pharma.
Tizanidine 2 mg – Zanaflex.
Cyclobenzaprine 15 mg ER – Skelebenz ER.
Methocarbamol 500 mg – Robaxin.

🎥 Educational Video on Baclofen

👨‍⚕️ Expert Insight: Dr. Ravi Shah, Neurologist

“Higher doses like 25 mg of Baclofen can manage more severe spasticity, but careful titration and monitoring are key to prevent sedation and hypotension.”