✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Ibuprofen
💊 Indication:	Severe Pain, Inflammation, Fever (Postoperative Pain, Dental Surgery, Rheumatic Conditions)
🇺🇸 US Brand:	Advil, Motrin
🏭 Manufacturer:	Abbott India Pvt Ltd (Founded: 1944)
📦 Packaging:	15 Tablets per Strip
🧪 Strength:	600 mg
🚚 Delivery Time:	6–15 days

🌡️ What is Ibuprofen 600 mg (Brufen 600)?

Brufen 600 mg is a high-strength ibuprofen formulation for managing severe pain and inflammation. As a nonsteroidal anti-inflammatory drug (NSAID), it nonselectively inhibits both COX-1 and COX-2 enzymes, reducing prostaglandin synthesis, thereby alleviating pain, swelling, and fever.

Pharmacodynamics studies show that a 600 mg dose achieves rapid pain relief within 30–60 minutes, with anti-inflammatory effects lasting up to 8 hours. This dose is ideal for acute postoperative, dental, or severe musculoskeletal pain.

For detailed prescribing and safety information, refer to the FDA label for Motrin and the Drugs.com monograph. The NHS Medicines A–Z entry and WHO Essential Medicines List offer additional guidance.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C13H18O2
Molecular Weight	206.28 g/mol
Bioavailability	~80–100%
Metabolism	Hepatic (CYP2C9)
Half-Life	~2 hours

Ibuprofen’s COX inhibition mitigates prostaglandin-mediated nociception, inflammation, and pyrexia.

💡 Indications & Dosing

Condition	Dose
Severe Acute Pain	600 mg every 6–8 hours as needed (max 1,800 mg/day)
Postoperative & Dental Pain	600 mg single dose; may repeat every 6 hrs if needed
Rheumatic Flare-Ups	600 mg twice daily with food (short-term)
Fever	600 mg single dose; repeat only if medically necessary

Always administer with food or milk to reduce gastrointestinal side effects. Avoid exceeding the maximum daily dose.

⚠️ Warnings & Side Effects

Common:

Gastrointestinal discomfort (nausea, dyspepsia)
Headache, dizziness
Edema

Serious:

Gastrointestinal bleeding, ulceration
Increased cardiovascular risk (MI, stroke)
Renal impairment, fluid retention

Use the lowest effective dose for the shortest duration. Monitor for GI, cardiovascular, and renal adverse events, especially in at-risk patients.

🏥 Storage Instructions

Store Brufen 600 mg at 20–25°C in original packaging, protected from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only for 600 mg strength; lower strengths OTC.
UK & EU: Prescription required; generic ibuprofen 600 mg available.
Australia: Prescription and TGA import approval required.

Importing from India may decrease cost; ensure regulatory compliance and valid prescription.

🔗 Related High-Potency NSAIDs

Ketoprofen 100 mg – potent NSAID.
Diclofenac 100 mg SR – extended-release.
Naproxen 500 mg – long-acting NSAID.
Meloxicam 15 mg – preferential COX-2 inhibitor.
Celecoxib 200 mg – selective COX-2 inhibitor.

🎥 Educational Video on High-Dose Ibuprofen

👩‍⚕️ Expert Insight: Dr. Priya Mehta, General Physician

“Brufen 600 mg provides powerful relief for acute severe pain. Ensure proper GI protection and monitor cardiovascular risk with high-dose NSAID therapy.”