✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Testosterone USP
💊 Indication:	Male Hypogonadism, Testosterone Replacement Therapy
🇺🇸 US Brand:	AndroGel®
🏭 Manufacturer:	Gufic Bioscience Ltd (Founded: 1984)
📦 Packaging:	80 g Tube
🧪 Strength:	1% Gel (10 mg testosterone per g)
🚚 Delivery Time:	6–15 days

🌿 What is Testosterone 1% Gel (Androfast)?

Androfast Gel contains 1% testosterone, delivering 10 mg per gram in a hydroalcoholic gel formulation. It is applied once daily to upper body skin, providing consistent transdermal delivery to achieve and maintain physiological testosterone levels in men with hypogonadism.

For prescribing details, safety guidance, and contraindications, refer to the FDA label for AndroGel®, the Drugs.com monograph, the NHS entry on testosterone therapy, and the WHO Model List of Essential Medicines.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C19H28O2
Molecular Weight	288.42 g/mol
Absorption	~10% per application (transdermal)
Metabolism	Hepatic (CYP3A4)
Half-Life	~10–100 minutes (serum); depot effect over 24 hrs

Transdermal testosterone bypasses first-pass metabolism, achieving stable serum levels and reducing hepatic adverse effects.

💡 Indications & Dosing

Condition	Dose & Administration
Male Hypogonadism	Apply 5 g gel (50 mg testosterone) once daily to clean, dry skin on shoulders, upper arms, or abdomen

Rub in thoroughly and allow to dry before dressing. Wash hands after application; cover treated area if swimming or showering within 2 hours.

⚠️ Warnings & Side Effects

Common:

Skin irritation at application site
Increased hematocrit
Acne, oily skin

Serious:

Secondary exposure risk to children and women (virilization)
Polycythemia
Cardiovascular events (risk in older men)

Contraindicated in prostate or breast cancer in men, pregnancy, and children. Monitor PSA, hematocrit, and lipid profile regularly.

🏥 Storage Instructions

Store Androfast Gel at 20–25°C. Protect from light. Keep tube tightly closed. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (AndroGel®) transdermal therapy.
UK & EU: Prescription required; various testosterone gels available.
Australia: Prescription and TGA approval needed.

Importing from India may reduce cost; ensure prescription validity and regulatory compliance.

🔗 Related Testosterone Therapies

Testosterone Enanthate Injection 250 mg/mL – IM depot.

🎥 Educational Video on Testosterone Replacement

👨‍⚕️ Expert Insight: Dr. Vikram Patel, Endocrinologist

“Transdermal testosterone gels like Androfast offer physiologic hormone replacement with stable serum levels and minimal hepatic load. However, patient education on application and secondary exposure prevention is crucial.”